Molecular signatures of disease brain endothelia provide new sites for CNS-directed enzyme therapy

Nature Medicine 15, 1215 - 1218 (2009)
Published online: 13 September 2009 | doi:10.1038/nm.2025

Yong Hong Chen¹, Michael Chang² & Beverly L Davidson^1,3

1. Department of Internal Medicine, Iowa City, Iowa, USA.
2. Departments of Molecular Physiology & Biophysics, Iowa City, Iowa, USA.
3. Department of Neurology, University of Iowa, Iowa City, Iowa, USA.

Keywors: Brain vasculature,  neural cells, microvessel,  enzyme replacement therapy, central nervous system (CNS), endothelia,  neurons,  glia, adeno-associated virus (AAV),  biodistribution.

Glutaredoxins: roles in iron homeostasis

Trends in Biochemical Sciences
Article in Press,
 
Nicolas Rouhier1, , Jérémy Couturier1, Michael K. Johnson2 and Jean-Pierre Jacquot1


1Unité Mixte de Recherches 1136 INRA Nancy University, Interactions Arbres Microorganismes, IFR 110 EFABA, Faculté des Sciences, BP 239 54506, Vandoeuvre Cedex, France
2Department of Chemistry and Center for Metalloenzyme Studies, University of Georgia, Athens, GA 30602, USA


Available online 5 October 2009.