Sunday, December 13, 2009

Clinical measures of dysarthria in Friedreich Ataxia

Movement Disorders, Early View (Articles online in advance of print),Published Online: 11 Dec 2009

Arunjot Singh, MS, Elizabeth Epstein, BA, Lauren M. Myers, BA, Jennifer M. Farmer, MS, David R. Lynch, MD, PhD
 Departments of Neurology and Pediatrics, University of Pennsylvania School of Medicine and The Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, USA

Keywords: ataxia, sensory neuron, dysarthria, balance, clinical trial, Friedreich Ataxia (FA), speech, therapeutic monitoring.

AF4 Is a Critical Regulator of the IGF-1 Signaling Pathway during Purkinje Cell Development

The Journal of Neuroscience, December 9, 2009, 29(49):15366-15374; doi:10.1523/JNEUROSCI.5188-09.2009

Emmanuelle Bitoun,1,2 * Mattéa J. Finelli,1,2 * Peter L. Oliver,1,2 Sheena Lee,1 and Kay E. Davies1,2
1Medical Research Council Functional Genomics Unit, and 2Department of Physiology, Anatomy and Genetics, University of Oxford, Oxford OX1 3QX, United Kingdom

 Keywords:  insulin-like growth factor 1 (IGF-1), cerebellar ataxia,  neuronal cell death, targeted for therapy,  Purkinje cell (PC) death, cerebellum, transcriptional cofactor.