Epigenetics specialists plan to edit the 'book of life'

FierceBiotech Research Newsletter, December 15, 2009

Repligen Receives Second Research Grant from the Muscular Dystrophy Association to Support Friedreich's Ataxia Preclinical Development Program

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Iron binding activity in yeast frataxin entails a trade off with stability in the α1/β1 acidic ridge region

Biochem. J. (2009) Immediate Publication, doi:10.1042/BJ20091612

Ana R. Correia, Tao Wang, Elizabeth A. Craig and Cláudio M. Gomes.
Instituto Tecnologia Química e Biológica, Oeiras 2785-572, Portugal.

Keywords: Frataxin, Friedreich’s ataxia (FRDA), progressive ataxia, cardiomyopathy, Fe-S assembly, Isu, functional regions, α1/β1 acidic ridge, β-sheet surface, iron binding region.

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Human ISCA1 Interacts with IOP1/NARFL and Functions in Both Cytosolic and Mitochondrial Iron-Sulfur Protein Biogenesis

Daisheng Song, Zheng Tu, Frank S. Lee.
From the Department of Pathology and Laboratory Medicine, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104

Keywords: Iron-sulfur proteins,  IscA,  isc (iron-sulfur cluster) operon,  IscA1,  succinate dehydrogenase,  mitochondrial aconitase, cytosolic aconitase, IOP1 (iron-only hydrogenase-like protein 1)/NARFL (nuclear prelamin A recognition factor-like).