Thursday, October 21, 2010

Frataxin is an important regulator of iron metabolism

MRC, National Institute for Medical Research, 20 October 2010

Brief summary of the article by Dr. Annalisa Pastore, explaining their research in words more simple and comprehensible to all

Frataxin depletion in yeast triggers upregulation of iron transport systems before affecting iron-sulfur enzyme activities.

J Biol Chem. 2010 Oct 18. [Epub ahead of print]
Moreno-Cermeno A, Obis E, Belli G, Cabiscol E, Ros J, Tamarit J.

University of Lleida, Spain.

Keywords: frataxin, a mitochondrial protein, iron homeostasis, yeast model, frataxin homolog YFH1, aconitase, secondary events, iron overloading, superoxide dismutase, protein carbonyl formation, manganese, metal ion transporter Smf2.

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