Monday, March 28, 2011

HDAC1 and HDAC2 control the transcriptional program of myelination and the survival of Schwann cells

Nature Neuroscience 14, 429–436, (2011) doi:10.1038/nn.2762
Published online, 20 March 2011.

Claire Jacob, Carlos N Christen, Jorge A Pereira, Christian Somandin, Arianna Baggiolini, Pirmin Lötscher, Murat Özçelik, Nicolas Tricaud, Dies Meijer, Teppei Yamaguchi, Patrick Matthias & Ueli Suter

In Schwann cells, HDAC1 and HDAC2 exert specific primary functions: HDAC2 activates the transcriptional program of myelination in synergy with Sox10, whereas HDAC1 controls Schwann cell survival.