Friday, December 9, 2011

Mutations in the dimer interface of dihydrolipoamide dehydrogenase promote site-specific oxidative damages in yeast and human cells

J. Biol. Chem. jbc.M111.274415. First Published on September 19, 2011, doi:10.1074/jbc.M111.274415

Rachael A. Vaubel, Pierre Rustin, and Grazia Isaya


DLD dimer interface mutations may accelerate frataxin turnover via an unknown mechanism

The role of DLD proteolytic activity remains unclear, and will require a better understanding of conditions that accelerate FXN turnover and the identification of additional natural substrates cleaved by DLD.