Friday, January 20, 2012

Effects of Friedreich's ataxia GAA repeats on DNA replication in mammalian cells

Nucl. Acids Res. (2012) doi: 10.1093/nar/gks021.

Gurangad S. Chandok 1, Mayank P. Patel 1, Sergei M. Mirkin 2 and Maria M. Krasilnikova
Department of Biochemistry and Molecular Biology, Penn State University, University Park, PA 16802 and 2Department of Biology, Tufts University.

Keyword: Friedreich's ataxia (FRDA),(GAA)n repeat, age-dependent instability, episomal DNA replication, chromatin.

Full text PDF