Wednesday, May 16, 2012

Resveratrol Protects Cortical Neurons against Microglia-mediated Neuroinflammation

Resveratrol Protects Cortical Neurons against Microglia-mediated Neuroinflammation, Zhang, F., Wang, H., Wu, Q., Lu, Y., Nie, J., Xie, X. and Shi, J. (2012), Phytother. Res.. doi: 10.1002/ptr.4734

 Keywords: resveratrol, neuroprotection, neuroinflammation, microglial activation, neurological disorders.

  I would like to stress that currently in Australia is running a clinical trial in FA patients, we are looking forward to its findings

TALE proteins induced the expression of the frataxin gene.

TALE proteins induced the expression of the frataxin gene. Prof. Jacques P Tremblay, Mr. Pierre Chapdelaine, Zoé Coulombe, and Joël Rousseau. Human Gene Therapy. -Not available-, ahead of print. doi:10.1089/hum.2012.034.

 The TALEFrat increased by 2 to 3 folds the frataxin gene expression and potentially could alleviate the symptoms of Friedreich ataxia.

Keywords: Tal effector proteins(TALE), transcription activator, expression of a gene, Friedreich ataxia (FRDA), frataxin, TALE genes (TALEFrat), VP16 peptides, mCherry reporter gene