Saturday, August 11, 2012

Iron-Sulfur Cluster Synthesis, Iron Homeostasis and Oxidative Stress in Friedreich Ataxia

Iron-Sulfur Cluster Synthesis, Iron Homeostasis and Oxidative Stress in Friedreich Ataxia; Rachael A. Vaubel, Grazia Isaya; Molecular and Cellular Neuroscience, Available online 10 August 2012, http://dx.doi.org/10.1016/j.mcn.2012.08.003

Keywords: frataxin, mitochondria, heme, oxidative stress, anti-oxidants, iron-chelators, ISC, iron-sulfur clusters, FRDA, Friedreich ataxia, NFS1/Nfs1, human/yeast cysteine desulfurase, ISD11/Isd11, human/yeast NFS1-/Nfs1-binding protein, ISCU/Isu1, human/yeast scaffold protein, MPP, mitochondrial processing peptidase.

The Essential Iron-Sulfur Protein Rli1 is an Important Target Accounting for Inhibition of Cell Growth by Reactive Oxygen Species

The Essential Iron-Sulfur Protein Rli1 is an Important Target Accounting for Inhibition of Cell Growth by Reactive Oxygen Species.Alhebshi A, Sideri TC, Holland SL, Avery SV.; Mol Biol Cell. 2012 Aug 1. Keywords: Oxidative stress, reactive oxygen species (ROS), molecular target(s), Rli1p (ABCE1), ROS-labile cofactors (Fe-S clusters).

Role of frataxin in erythropoietin- and carbamoylated erythropoietin- mediated neuroprotective effects in the mouse retina after acute retinal ischemia/reperfusion in vivo

Role of frataxin in erythropoietin- and carbamoylated erythropoietin- mediated neuroprotective effects in the mouse retina after acute retinal ischemia/reperfusion in vivo. Rowena Schultz, Otto W Witte, Christian Schmeer F1000 Posters 2012, 3: 889 (poster); Presented at 7th International Symposium on Neuroprotection and Neurorepair 2012, 2 - 5 May 2012, PIII -40

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Quantitative Analysis to Guide Orphan Drug Development

Quantitative Analysis to Guide Orphan Drug Development.L J Lesko. Clinical Pharmacology & Therapeutics (2012); 92 2, 258–261. doi:10.1038/clpt.2012.80

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