Human mitochondrial ferritin improves respiratory function in yeast mutants deficient in iron-sulfur cluster biogenesis, but is not a functional homologue of yeast frataxin.

Human mitochondrial ferritin improves respiratory function in yeast mutants deficient in iron-sulfur cluster biogenesis, but is not a functional homologue of yeast frataxin.Sutak R, Seguin A, Garcia-Serres R, Oddou JL, Dancis A, Tachezy J, Latour JM, Camadro JM, Lesuisse E.; Microbiologyopen. 2012 Jun;1(2):95-104.

Keywords: human mitochondrial ferritin, frataxin-deficient yeast cells (Δyfh1), mitochondrial iron, insoluble particles of ferric phosphate, deficient in [Fe-S] assembly, functional homologue.

Genome-wide Screen Identifies Pathways that Govern GAA/TTC Repeat Fragility and Expansions in Dividing and Nondividing Yeast Cells

Genome-wide Screen Identifies Pathways that Govern GAA/TTC Repeat Fragility and Expansions in Dividing and Nondividing Yeast Cells; Yu Zhang, Alexander A. Shishkin, Yuri Nishida, Dana Marcinkowski-Desmond, Natalie Saini, Kirill V. Volkov, Sergei M. Mirkin, Kirill S. Lobachev; Molecular Cell, Available online 6 September 2012, http://dx.doi.org/10.1016/j.molcel.2012.08.002

Keywords: Triplex structure-forming GAA/TTC repeats, gene inactivation, Friedreich’s ataxia, chromosomal fragile sites, chromosomal rearrangements, DNA replication.

Re-purposing small-molecule drugs to treat the mitochondrial disease Friedreich's ataxia

Re-purposing small-molecule drugs to treat the mitochondrial disease Friedreich's ataxia;Sunil Sahdeo, Mark Pook, Marek Napierala, Joe Sarsero, Gino Cortopassi; Mitochondrion, Volume 12, Issue 5, September 2012, Pages 571-572, http://dx.doi.org/10.1016/j.mito.2012.07.056

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Neurodegenerative disease: Microglia in early disease stages

Neurodegenerative disease: Microglia in early disease stages; Katie Kingwell; Nature Reviews Neurology 8, 475 (September 2012) | doi:10.1038/nrneurol.2012.172

Keywords: neurodegenerative diseases, microglia-mediated CNS inflammation, therapeutic targets and strategies.