Tuesday, March 26, 2013

Synthesis of Benzoquinone Antioxidants and a Bleomycin Disaccharide Library

Synthesis of Benzoquinone Antioxidants and a Bleomycin Disaccharide Library. Mathilakathu Madathil, Manikandadas (Author) / Hecht, Sidney M (Advisor) / Rose, Seth (Committee member) / Woodbury, Neal (Committee member) / Arizona State University (Publisher).; Doctoral Dissertation, ASU Electronic Dissertations and Theses (2013)

The synthesized 5-amino-3-tridecyl-1,4-benzoquinone antioxidants were tested for their ability to protect Friedreich's ataxia (FRDA) lymphocytes from induced oxidative stress. Some of the analogues synthesized conferred cytoprotection in a dose-dependent manner in FRDA lymphocytes at micromolar concentrations.



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Assessment of upper limb function in young Friedreich ataxia patients compared to control subjects using a new three-dimensional kinematic protocol

Assessment of upper limb function in young Friedreich ataxia patients compared to control subjects using a new three-dimensional kinematic protocol.
Nathalie Maurel, Amadou Diop, Arnaud Gouelle, Corinne Alberti, Isabelle Husson; Clinical Biomechanics, Available online 26 March 2013. http://dx.doi.org/10.1016/j.clinbiomech.2013.02.007

Keywords: Friedreich ataxia, Evaluation of upper limb function, Three-dimensional kinematic protocol, Reliability, Measurement errors, Discriminative ability.