SIRT3 regulates cellular iron metabolism and cancer growth by repressing iron regulatory protein 1; S M Jeong, J Lee, L W S Finley, P J Schmidt, M D Fleming and M C Haigis; Oncogene advance online publication 9 June 2014; doi: 10.1038/onc.2014.124
The activity of SIRT3 is inhibited in frataxin-deficient heart, it may contribute to the cardiomyopathy in Friedreich’s ataxia. Friedreich’s ataxia cells exhibit an increased IRP1 activity and iron accumulation, thus, it will be interesting for future studies to examine the role of SIRT3 in systemic iron homeostasis and iron-related human diseases.
Tuesday, June 10, 2014
Autologous Stem Cell Transplant with Gene Therapy for Friedreich Ataxia
Autologous Stem Cell Transplant with Gene Therapy for Friedreich Ataxia; P.T. Naoki Tajiri, B.S. Meaghan Staples, Yuji Kaneko, Seung U. Kim, Theresa A. Zesiewic, Cesar V. Borlongan, Medical Hypotheses, Available online 9 June 2014, ISSN 0306-9877, http://dx.doi.org/10.1016/j.mehy.2014.05.022.
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