Selective dendritic susceptibility to bioenergetic and redox perturbations in cortical neurons

Selective dendritic susceptibility to bioenergetic and redox perturbations in cortical neurons. Philip Hasel, Sean Mckay, Jing Qiu, Giles E. Hardingham; Biochimica et Biophysica Acta (BBA) - Molecular Cell Research, Available online 22 December 2014, ISSN 0167-4889, http://dx.doi.org/10.1016/j.bbamcr.2014.12.021.

Deregulation of glutathione homeostasis and other antioxidant systems is implicated in the aetiology of several neurodegenerative disorders associated with dendritic pathologies, including: Alzheimer's disease, Huntington's disease, ALS Friedreich's ataxia, and Parkinson's disease, and activation of GSH pathway enzymes, particularly in astrocytes, is a potential therapeutic strategy for combating oxidative stress in the brain.

Transition of Thalassaemia and Friedreich ataxia from fatal to chronic diseases

Transition of Thalassaemia and Friedreich ataxia from fatal to chronic diseases. Annita Kolnagou, Christina N Kontoghiorghe, and George J Kontoghiorghes; World J Methodol. Dec 26, 2014; 4(4): 197–218. Published online Dec 26, 2014. doi: 10.5662/wjm.v4.i4.197

Highly specific ubiquitin-competing molecules effectively promote frataxin accumulation and partially rescue the aconitase defect in Friedreich ataxia cells

Highly specific ubiquitin-competing molecules effectively promote frataxin accumulation and partially rescue the aconitase defect in Friedreich ataxia cells. Alessandra Rufini, Francesca Cavallo, Ivano Condo’, Silvia Fortuni, Gabriella De Martino, Ottaviano Incani, Almerinda Di Venere, Monica Benini, Damiano Sergio Massaro, Gaetano Arcuri, Dario Serio, Florence Malisan, Roberto Testi; Neurobiology of Disease, Available online 27 December 2014, ISSN 0969-9961, http://dx.doi.org/10.1016/j.nbd.2014.12.011.

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