Frataxin knockdown in human astrocytes triggers cell death and the release of factors that cause neuronal toxicity. Frida Loría, Javier Díaz-Nido, Neurobiology of Disease, Available online 29 December 2014, ISSN 0969-9961, http://dx.doi.org/10.1016/j.nbd.2014.12.017.
Findings confirm a detrimental effect of frataxin silencing, not only for astrocytes, but also for neuron-glia interactions, underlining the need to take into account the role of non-cell autonomous processes in FA.
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