Sunday, April 5, 2015

Effect of mental fatigue on speed-accuracy trade-off

Effect of mental fatigue on speed-accuracy trade-off. Vianney Rozand, Florent Lebon, Charalambos Papaxanthis, Romuald Lepers, Neuroscience, Available online 4 April 2015, ISSN 0306-4522, http://dx.doi.org/10.1016/j.neuroscience.2015.03.066.

Previous studies suggested that the speed-accuracy trade-off is altered in specific cases, e.g., the patients with Friedreich ataxia that alter motor coordination but not cognitive functions (Corben et al., 2011) or the elderly (Sleimen-Malkoun et al., 2013). In these populations, movement duration was slowed compared to healthy young subjects, especially for higher difficulties.

Autophagy in neurodegenerative diseases: from pathogenic dysfunction to therapeutic modulation

Autophagy in neurodegenerative diseases: from pathogenic dysfunction to therapeutic modulation. Marta Martinez-Vicente, Seminars in Cell & Developmental Biology, Available online 2 April 2015, ISSN 1084-9521, http://dx.doi.org/10.1016/j.semcdb.2015.03.005.

Autophagic dysfunction has been described in many neurodegenerative diseases, ranging from Alzheimer’s disease (AD), to Parkinson’s disease (PD), Huntington’s disease (HD), amyotrophic lateral sclerosis (ALS), Friedreich's ataxia and others. Failure of the autophagic process may thus be one of the factors contributing to neuronal cell death