The Structure of the Complex Between Yeast Frataxin and Ferrochelatase: Characterization and pre-Steady State Reaction of Ferrous Iron Delivery and Heme Synthesis

Christopher G. Soderberg, Mallory E. Gillam, Eva-Christina Ahlgren, Gregory A. Hunter, Oleksandr Gakh, Grazia Isaya, Gloria C. Ferreira and Salam Al-Karadaghi, The Journal of biological chemistry: 2016 First Published on March 29, 2016, doi: 10.1074/jbc.M115.701128

They support the proposal that frataxin-mediated delivery of this potentially toxic substrate (Fe2+)overcomes formation of reactive oxygen species.