Tuesday, March 10, 2020

Outlining the Complex Pathway of Mammalian Fe-S Cluster Biogenesis

Nunziata Maio, Tracey A. Rouault; Trends in Biochemical Sciences, 2020, doi:10.1016/j.tibs.2020.02.001.

Structural determinations of the architecture of the initial ISC biogenesis complex, comprising NFS1, ISD11, ACP, ISCU, and FXN, have shed light on the interactions that govern de novo ISC assembly.