Ignacio Hugo Castro, Mauro Bringas, Davide Doni, Martin Ezequiel Noguera, Luciana Capece, Martín Aran, Matías Blaustein, Paola Costantini, Javier Santos; Archives of Biochemistry and Biophysics, 2020, 108491, doi:10.1016/j.abb.2020.108491.
In this study, we prepared a set of FXN variants spanning a broad range of conformational stabilities. Variants S160I, S160 M and A204R were more stable than the wild-type and showed similar biological activity. We concluded that the contribution of particular side chains to the conformational stability of FXN might be highly subordinated to their impact on both the protein function and the stability of the functional supercomplex.
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