Friedreich Ataxia and close related scientific news. Topics related to rare diseases.
Tuesday, December 15, 2009
Epigenetics specialists plan to edit the 'book of life'
FierceBiotech Research Newsletter, December 15, 2009
Iron binding activity in yeast frataxin entails a trade off with stability in the α1/β1 acidic ridge region
Biochem. J. (2009) Immediate Publication, doi:10.1042/BJ20091612
Ana R. Correia, Tao Wang, Elizabeth A. Craig and Cláudio M. Gomes.
Instituto Tecnologia Química e Biológica, Oeiras 2785-572, Portugal.
Keywords: Frataxin, Friedreich’s ataxia (FRDA), progressive ataxia, cardiomyopathy, Fe-S assembly, Isu, functional regions, α1/β1 acidic ridge, β-sheet surface, iron binding region.
Full text pdf
Ana R. Correia, Tao Wang, Elizabeth A. Craig and Cláudio M. Gomes.
Instituto Tecnologia Química e Biológica, Oeiras 2785-572, Portugal.
Keywords: Frataxin, Friedreich’s ataxia (FRDA), progressive ataxia, cardiomyopathy, Fe-S assembly, Isu, functional regions, α1/β1 acidic ridge, β-sheet surface, iron binding region.
Full text pdf
Human ISCA1 Interacts with IOP1/NARFL and Functions in Both Cytosolic and Mitochondrial Iron-Sulfur Protein Biogenesis
Daisheng Song, Zheng Tu, Frank S. Lee.
From the Department of Pathology and Laboratory Medicine, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104
Keywords: Iron-sulfur proteins, IscA, isc (iron-sulfur cluster) operon, IscA1, succinate dehydrogenase, mitochondrial aconitase, cytosolic aconitase, IOP1 (iron-only hydrogenase-like protein 1)/NARFL (nuclear prelamin A recognition factor-like).
From the Department of Pathology and Laboratory Medicine, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104
Keywords: Iron-sulfur proteins, IscA, isc (iron-sulfur cluster) operon, IscA1, succinate dehydrogenase, mitochondrial aconitase, cytosolic aconitase, IOP1 (iron-only hydrogenase-like protein 1)/NARFL (nuclear prelamin A recognition factor-like).