Vitamin Switches on a Gene, A Potential New Treatment for Friedreich's Ataxia?. MRC Clinical Sciences Centre, Faculty of Medicine, Imperial College London.
Novel research from the CSC holds promise for a new therapeutic approach, using a commonly available vitamin supplement to modify the epigenetic controls of the genetic defect causing the illness.
Related to: Heterochromatinization induced by GAA-repeat hyperexpansion in Friedreich's ataxia can be reduced upon HDAC inhibition by Vitamin B3
Friedreich Ataxia and close related scientific news. Topics related to rare diseases.
Wednesday, April 10, 2013
Frataxin Deficiency Leads to Reduced Expression and Impaired Translocation of NF-E2-Related Factor (Nrf2) in Cultured Motor Neurons
Frataxin Deficiency Leads to Reduced Expression and Impaired Translocation of NF-E2-Related Factor (Nrf2) in Cultured Motor Neurons. D'Oria, V.; Petrini, S.; Travaglini, L.; Priori, C.; Piermarini, E.; Petrillo, S.; Carletti, B.; Bertini, E.; Piemonte, F.; International Journal of Molecular Sciences. 2013; 14(4):7853-7865.
OPEN ACCESS
OPEN ACCESS