Saturday, January 7, 2023

Drosophila melanogaster frataxin: protein crystal and predicted solution structure with identification of the iron-binding regions

Rodrigues AV, Batelu S, Hinton TV, Rotondo J, Thompson L, Brunzelle JS, Stemmler TL.; Acta Crystallogr D Struct Biol. 2023 Jan 1;79(Pt 1):22-30. doi: 10.1107/S2059798322011639. Epub 2023 Jan 1. PMID: 36601804. 

 The goal of this report is to provide structural details of the Drosophila melanogaster frataxin ortholog (Dfh), using both X-ray crystallography and nuclear magnetic resonance (NMR) spectroscopy, in order to provide the foundational insight needed to understand the structure-function correlation of the protein.