EvolClustDB: exploring eukaryotic gene clusters with evolutionarily conserved genomic neighbourhoods, Journal of Molecular Biology

Marcet-Houben, M., Collado-Cala, I., Fuentes-Palacios, D., Gómez, A. D., Molina, M., Garisoain-Zafra, A., … Gabaldón, T. (2023). EvolClustDB: exploring eukaryotic gene clusters with evolutionarily conserved genomic neighbourhoods. Journal of Molecular Biology, (168013), 168013. doi:10.1016/j.jmb.2023.168013 

The search also revealed that there were multiple CF found in the insect dataset containing Frataxin homologs (CI_005786, CI_005711, CI_005644, CI_000213, among others) and in the fungal dataset (CF_012296 and CF_009163). This shows that the Frataxin genomic context tends to be conserved, but that the specific neighboring genes are clade-specific. The functional relationship between the Frataxin-surrounding genes and Frataxin in the different clades is unknown and deserves further investigation.