Harding, I.H., Nur Karim, M.I., Selvadurai, L.P., Corben, L.A., Delatycki, M.B., Monti, S., Saccà, F., Georgiou-Karistianis, N., Cocozza, S. and Egan, G.F. (2024), Localized Changes in Dentate Nucleus Shape and Magnetic Susceptibility in Friedreich Ataxia. Mov Disord. doi:10.1002/mds.29816
Changes in the structure of the dentate nuclei in FRDA are not spatially uniform. Atrophy is greatest in areas with high gray matter density, whereas increases in susceptibility—reflecting iron concentration, demyelination, and/or gliosis—predominate in the medial white matter.