Thursday, February 18, 2010

Atypical, perhaps under-recognized? An unusual phenotype of Friedreich ataxia

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Neurogenetics, 10.1007/s10048-009-0233-x Beate Diehl1, Michael S. Lee2, Janet R. Reid3, Craig D. Nielsen4 and Marvin R. Natowicz5, 6 Conta...
Wednesday, February 17, 2010

FRIEDREICH'S ATAXIA: MOLECULAR MECHANISMS, REDOX CONSIDERATIONS AND THERAPEUTIC OPPORTUNITIES

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Antioxid Redox Signal. 2010 Feb 16. Santos R, Lefevre S, Sliwa D, Seguin A, Camadro JM, Lesuisse E. Institut Jacques Monod, Mitochondria,...

Posttranslational stability of the heme biosynthetic enzyme ferrochelatase is dependent on iron availability and intact iron-sulfur cluster assembly machinery

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Blood, 28 January 2010, Vol. 115, No. 4, pp. 860-869. Daniel R. Crooks1,2, Manik C. Ghosh2, Ronald G. Haller3, Wing-Hang Tong2, and Tracey...
Tuesday, February 16, 2010

R loops stimulate genetic instability of CTG·CAG repeats

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PNAS, Edited by Philip C. Hanawalt, Stanford University, Stanford, CA, and approved November 27, 2009 (received for review August 26, 2009) ...

Safety issues of iron chelation therapy in patients with normal range iron stores including thalassaemia, neurodegenerative, renal and infectious diseases

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Expert Opinion on Drug Safety. Posted online on 09 Jan 2010. G J Kontoghiorghes‌†1, A Kolnagou‌2, C-T Peng‌3, S V Shah‌4 & A Aessopos‌...
Thursday, February 11, 2010

Immunobiology of gene therapy for neurodegenerative disease: prospects and risks

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Gene Therapy advance online publication 11 February 2010; doi: 10.1038/gt.2010.2 M M McMenamin1 and M J A Wood Department of Physiology, ...
Wednesday, February 10, 2010

New hope in hunt for ataxia cure

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theage.com.au 6:22AM Thu February 11, 2010 NICK MILLER -february 11, 2010   Teams from the University of M...

Frataxin, a molecule of mystery: trading stability for function in its iron-binding site

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Biochem. J. (2010) 426 (e1–e3) (Printed in Great Britain) Darius J. R. Lane* and Des R. Richardson†1 *Department of Biochemistry and Mole...
Sunday, February 7, 2010

Overcoming frataxin gene silencing in Friedreich’s ataxia with small molecules: studies on cellular and animal models

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Rai, Myriam. F204 - Faculté de médecine - Sciences biomédicales Doctorat en sciences biomédicales, Date de défense 2010-01-05 Keywords: f...
Thursday, February 4, 2010

Diazoxide for the treatment of Friedreich's Ataxia

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United States Patent Application 20100029576 Kind Code:A1 Inventors: Marobbio, Carlo Marya Thomas (Bari, IT) , Palmeri, Luigi (Bari, IT), ...