Thursday, October 21, 2010

Frataxin is an important regulator of iron metabolism

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MRC, National Institute for Medical Research, 20 October 2010 Brief summary of the article by Dr. Annalisa Pastore, explaining their resea...

Frataxin depletion in yeast triggers upregulation of iron transport systems before affecting iron-sulfur enzyme activities.

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J Biol Chem. 2010 Oct 18. [Epub ahead of print] Moreno-Cermeno A, Obis E, Belli G, Cabiscol E, Ros J, Tamarit J. University of Lleida, Sp...
Wednesday, October 20, 2010

Pharmacokinetic evaluation of idebenone.

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Expert Opin Drug Metab Toxicol. 2010 Nov;6(11):1437-44. Becker C, Bray-French K, Drewe J. Basel Pharmacoepidemiology Unit, University Hos...

Pathogenesis of impaired glucose tolerance and diabetes in Friedreich's ataxia: contribution of insulin resistance and pancreatic beta cell dysfunction.

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The free library, Miriam Cnop, MD, PhD, Universite Libre de Bruxelles, Brussels, Belgium Research summary Keywords: pancreatic b cells,...
Tuesday, October 19, 2010

Structural bases for the interaction of frataxin with the central components of iron–sulphur cluster assembly

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Nature Communications, Volume:1, Article number: 95, DOI: doi:10.1038/ncomms1097 Received 08 June 2010, Accepted 22 September 2010, Publish...

Mitochondrial ROS Generation and Its Regulation: Mechanisms Involved in H2O2 Signaling

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Antioxidants & Redox Signaling. Online Ahead of Print: October 18, 2010, doi:10.1089/ars.2010.3363. Michel Rigoulet, Edgar D. Yoboue, A...

Public summary of opinion on orphan designationN-(6-(2-aminophenylamino)-6-oxohexyl)-4-methylbenzamide for the treatment of Friedreich’s ataxia,

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12 October 2010 EMA/COMP/455242/2010 Committee for Orphan Medicinal Products. On 1 October 2010, orphan designation (EU/3/10/793) was gr...
Sunday, October 17, 2010

Induced pluripotency: history, mechanisms, and applications

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Genes & Dev. 2010. 24: 2239-2263, doi: 10.1101/gad.1963910 Matthias Stadtfeld, Konrad Hochedlinger (REVIEWS) OPEN ACCESS The ...
Thursday, October 14, 2010

In vivo evidence for the iron binding activity of an iron-sulfur cluster assembly protein IscA in Escherichia co

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Biochem. J. (2010) Immediate Publication, doi:10.1042/BJ20101507 Wu Wang, Hao Huang, Guoqiang Tan, Fan Si, Min Liu, Aaron P. Landry, Jianx...

Epigenetic modifications and human disease

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Nature Biotechnology, Volume:28, Pages:1057–1068,Year published:(2010) DOI:10.1038/nbt.1685, Published online 13 October 2010 Anna Portel...