Thursday, February 18, 2016

Intrathecal delivery of frataxin mRNA encapsulated in lipid nanoparticles to dorsal root ganglia as a potential therapeutic for Friedreich’s ataxia

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Joseph F. Nabhan, Kristy M. Wood, Varada P. Rao, Jeffrey Morin, Surya Bhamidipaty, Timothy P. LaBranche, Renea L. Gooch, Fazli Bozal, Christ...

Understanding the Role of Mitochondrial Pathophysiology in Friedreich's Ataxia

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Rosella Abeti, Michael H. Parkinson, Iain P. Hargreaves, Mark A. Pook, Andrey Y. Abramov, Paola Giunti, Biophysical Journal, Volume 110, Iss...
Wednesday, February 17, 2016

Scientists find potential treatment for Friedreich’s ataxia

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UT Southwestern, Newsroom. DALLAS – Feb. 16, 2016 – Researchers at UT Southwestern Medical Center have identified synthetic RNA and DNA that...
Tuesday, February 16, 2016

Astrocyte Resilience to Oxidative Stress Induced by Insulin-like Growth Factor I (IGF-I) Involves Preserved AKT (Protein Kinase B) Activity

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David Dávila, Silvia Fernández and Ignacio Torres-Alemán; The Journal of Biological Chemistry, 291, 2510-2523. doi: 10.1074/jbc.M115.69547...
Saturday, February 13, 2016

Energy metabolism in neuronal/glial induction and iPSC-based modeling of brain disorders

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Barbara Mlody, Carmen Lorenz, Gizem Inak, Alessandro Prigione; Seminars in Cell & Developmental Biology, Available online 11 February 20...
Friday, February 12, 2016

Usefulness of plasma high sensitive troponin t and Nt-proBNP in the diagnosis of cardiopathy in Friedreich ataxia,

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Lise Legrand, Carole Maupain, Marie Lorraine Monin, Alina Tataru, Alexandra Durr, Françoise Pousset, Richard Isnard; Archives of Cardiovascu...
Wednesday, February 10, 2016

Human Frataxin Folds Via an Intermediate State. Role of the C-Terminal Region

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Santiago E. Faraj, Rodolfo M. González-Lebrero, Ernesto A. Roman & Javier Santos; (Nature) Scientific Reports 6, Article number: 20782 (...
Tuesday, February 9, 2016

Ferroptosis: process and function

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Y Xie, W Hou, X Song, Y Yu1, J Huang, X Sun, R Kang and D Tang; Cell Death and Differentiation (2016) 23, 369–379; doi:10.1038/cdd.2015.158;...
Sunday, February 7, 2016

Gene transfer of brain derived neurotrophic factor (BDNF) prevents neurodegeneration triggered by frataxin deficiency

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Y Katsu-Jiménez, F Loria, JC Corona, and J Diaz-Nido; Molecular Therapy accepted article preview 5 February 2016; doi: 10.1038/mt.2016.32 ...
Saturday, February 6, 2016

Activating frataxin expression by repeat-targeted nucleic acids

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Liande Li, Masayuki Matsui & David R. Corey; Nature Communications 7, Article number: 10606 doi:10.1038/ncomms10606 Iintroducing anti-...