Thursday, March 2, 2017

Iron Accumulation, Glutathione Depletion, and Lipid Peroxidation Must Occur Simultaneously during Ferroptosis and are Mutually Amplifying Events

›
Robert L. Bertrand, Medical Hypotheses, Available online 28 February 2017, ISSN 0306-9877, doi:10.1016/j.mehy.2017.02.017. It is proposed ...
Friday, February 24, 2017

Measuring Inhibition and Cognitive Flexibility in Friedreich Ataxia

›
Louise A. Corben, Felicity Klopper, Monique Stagnitti, Nellie Georgiou-KaristianisJohn L. Bradshaw, Gary RanceMartin B. Delatycki; Cerebell...
Wednesday, February 22, 2017

E3 Ligase RNF126 Directly Ubiquitinates Frataxin, Promoting Its Degradation: Identification of a Potential Therapeutic Target for Friedreich Ataxia

›
Monica Benini, Silvia Fortuni, Ivano Condò, Giulia Alfedi, Florence Malisan, Nicola Toschi, Dario Serio, Damiano Sergio Massaro, Gaetano Arc...
Thursday, February 16, 2017

A study of CTI-1601 for the treatment of Friedreich's Ataxia.

›
Adis International Ltd. Part of Springer Science+Business Media, Trials Planning Phase of Trial: Phase I Latest Information Update: 14 ...
Tuesday, February 14, 2017

Health technology assessment of drugs for rare diseases: insights, trends, and reasons for negative recommendations from the CADTH common drug review

›
Ghayath Janoudi, William Amegatse, Brendan McIntosh, Chander Sehgal, and Trevor Richter; Orphanet J Rare Dis. 2016; 11: 164. doi:10.1186/s13...
Saturday, February 11, 2017

Industrializing rare disease therapy discovery and development

›
Sean Ekins; Nature Biotechnology 35, 117–118 (2017) doi:10.1038/nbt.3787 Published online 08 February 2017 There would also need to be clo...
Friday, February 10, 2017

Mitochondria-penetrating peptides conjugated to desferrioxamine as chelators for mitochondrial labile iron

›
Alta RYP, Vitorino HA, Goswami D, Liria CW, Wisnovsky SP, Kelley SO, Machini MT, Espósito BP. (2017). PLoS ONE 12(2): e0171729. doi:10.1371/...
Thursday, February 9, 2017

Shire divests mRNA platform to RaNa

›
Nature Biotechnology 35,103 (2017) doi:10.1038/nbt0217-103b Published online 08 February 2017 The Shire deal includes preclinical drug pro...
Wednesday, February 8, 2017

Comparison of Two Different PCR-based Methods for Detection of GAA Expansions in Frataxin Gene

›
Mona ENTEZA­M, Akbar AMIRFIROOZI, Mansoureh TOGHA, Mohammad KERAMATIPOUR; Iranian Journal of Public Health 2017. 46(2):222-228. The presen...
Tuesday, February 7, 2017

Chondrial Therapeutics Secures Up to $22.6 Million in Series A Financing and Licenses Novel Technology for the Treatment of Friedreich's Ataxia

›
PR Newswire, News provided by Chondrial Therapeutics, Inc. Feb 06, 2017, Company Plans to Advance Pipeline of Product Candidates Focused on...