Saturday, August 26, 2017

Are Astrocytes the Predominant Cell Type for Activation of Nrf2 in Aging and Neurodegeneration?

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Jeffrey R. Liddell, Antioxidants 2017, 6(3), 65; doi:10.3390/antiox6030065 This review describes the evidence for Nrf2 activation in each ...
Wednesday, August 23, 2017

Jupiter Orphan Therapeutics Receives Orphan Drug Designation for its Trans-Resveratrol Product JOTROL for Treatment of Friedreich's Ataxia

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JUPITER, Fla., Aug. 22, 2017 /PRNewswire/ -- Jupiter Orphan Therapeutics, Inc. ("JOT"), Jupiter, FL, today announced that it has r...
Tuesday, August 22, 2017

Assessment of glutathione/glutathione disulphide ratio and S-glutathionylated proteins in human blood, solid tissues, and cultured cells

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Daniela Giustarini, Graziano Colombo, Maria Lisa Garavaglia, Emanuela Astori, Nicola Marcello Portinaro, Francesco Reggiani, Salvatore Badal...
Monday, August 21, 2017

European Reference networks for rare diseases: what is the conceptual framework?

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Véronique Héon-Klin, Orphanet Journal of Rare Diseases 201712:137 doi:10.1186/s13023-017-0676-3 In February 2017, 24 European Reference Ne...
Sunday, August 20, 2017

Advances in Neurological Therapeutics for Friedreich Ataxia and Machado-Joseph Disease

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Yabe I, Sasaki H.; Brain Nerve. 2017 Aug;69(8):913-924. doi: 10.11477/mf.1416200842. [Article in Japanese] We reviewed advances in therape...
Friday, August 18, 2017

Cerebral Abnormalities in Friedreich Ataxia: A Review

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Louisa P. Selvadurai, Ian H. Harding, Louise A. Corben, Nellie Georgiou-Karistianis, Neuroscience & Biobehavioral Reviews, Available onl...
Thursday, August 17, 2017

Tocotrienols: the unsaturated sidekick shifting new paradigms in vitamin E therapeutics

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Madhu M. Kanchi, Muthu K. Shanmugam, Grishma Rane, Gautam Sethi, Alan P. Kumar, Drug Discovery Today, 2017, ISSN 1359-6446, doi:10.1016/j.d...

Targeting Mitochondrial Dysfunction in Neurodegenerative Disease

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The Dana Foundation. By Kayt Sukel, August 15, 2017 It’s long been known that the brain is an energy glutton: Most estimates suggest that...
Wednesday, August 16, 2017

Mechanisms of unexpected death and autopsy findings in Friedreich ataxia

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Roger W Byard, , John D Gilbert; Medicine, Science and the Law, First published date: August-13-2017, Doi:10.1177/0025802417723809 A 36-ye...
Tuesday, August 15, 2017

FDA Confirms That Use of mFARS as Primary Endpoint in Part 2 of the MOXIe Trial Can Support Approval of Omaveloxolone in Friedreich’s Ataxia

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RVING, Texas, Aug. 14, 2017 (GLOBE NEWSWIRE) -- Reata Pharmaceuticals, Inc. (Nasdaq:RETA) (“Reata” or the “Company”), a clinical-stage bioph...