Friday, July 27, 2018

Monash plant science discovery may unlock treatment strategies for genetic diseases in humans

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SOURCE Monash University SYDNEY, July 26, 2018 /PRNewswire/ -- Monash plant scientists have discovered a new molecular mechanism of gene r...

RNA-Dependent Epigenetic Silencing Directs Transcriptional Downregulation Caused by In- tronic Repeat Expansions

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Hannes Eimer, Sridevi Sureshkumar, Avilash Singh Yadav, Calvin Kraupner-Taylor, Champa Bandaranayake, Andrei Seleznev, Tamblyn Thomason, Ste...
Thursday, July 26, 2018

Identification of cardioprotective drugs by medium-scale in vivo pharmacological screening on a Drosophila cardiac model of Friedreich's ataxia

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Amandine Palandri, Elodie Martin, Maria Russi, Michael Rera, Hervé Tricoire, Véronique Monnier; Disease Models & Mechanisms 2018 11: dmm...
Tuesday, July 24, 2018

PTC Therapeutics to Acquire Agilis Biotherapeutics

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Medical Buyer Bureau. July 23, 2018. PTC Therapeutics to Acquire Agilis Biotherapeutics. We are impressed with the clinical results shown ...
Monday, July 23, 2018

Zinc(II) binding on human wild-type ISCU and Met140 variants modulates NFS1 desulfurase activity

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Nicholas G. Fox, Alain Martelli, Joseph F. Nabhan, Jay Janz, Oktawia Borkowska, Christine Bulawa, Wyatt W. Yue, Biochimie, 2018, doi:10.1016...

Genome damage from CRISPR/Cas9 gene editing higher than thought

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ScienceDaily, 19 July 2018. Scientists at the Wellcome Sanger Institute have discovered that CRISPR/Cas9 gene editing can cause greater gene...

Inherited Cardiomyopathies and the Role of Mutations in Non-coding Regions of the Genome

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Salman OF, El-Rayess HM, Abi Khalil C, Nemer G and Refaat MM (2018). Front. Cardiovasc. Med. 5:77. doi: 10.3389/fcvm.2018.00077 Although t...

Sodium magnetic resonance imaging in Friedreich ataxia – A preliminary study

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J.S. Krahe, S. Romanzetti, I. Dogan, C. Didszun, J.B. Schulz, K. Reetz, Clinical Neurophysiology, Volume 129, Issue 8, 2018, Pages e71-e72, ...

Novel Nrf2-Inducer Prevents Mitochondrial Defects and Oxidative Stress in Friedreich’s Ataxia Models

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Abeti R, Baccaro A, Esteras N and Giunti P (2018); Front. Cell. Neurosci. 12:188. doi: 10.3389/fncel.2018.00188 Omaveloxolone was protecti...
Sunday, July 22, 2018

Activating frataxin expression by single-stranded siRNAs targeting the GAA repeat expansion

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Xiulong Shen, Audrius Kilikevicius, Daniel O'Reilly, Thazha P. Prakash, Masad J. Damha, Frank Rigo, David R. Corey, Bioorganic & Med...