Saturday, July 28, 2018

Public offering nets $203mm for Reata

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Strategic Transactions. Jul 2018 Executive Summary Reata Pharmaceuticals Inc. (developing drugs targeting molecular pathways that regulate...

Double-blind, randomized and controlled trial of EPI-743 in Friedreich's ataxia

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Theresa Zesiewicz, Jason L Salemi, Susan Perlman, Kelly L Sullivan, Jessica D Shaw, Yangxin Huang, Charles Isaacs, Clifton Gooch, David R Ly...

Phenothiazine antioxidants increase mitochondrial biogenesis and frataxin levels in Friedreich’s Ataxia cells

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Omar Khdour, Indrajit Bandyopadhyay, Nishant Visavadiya, Sandipan Roy Chowdhury, Sidney M Hecht; MedChemComm ( IF 2.342 ) Pub Date : 2018-0...
Friday, July 27, 2018

Monash plant science discovery may unlock treatment strategies for genetic diseases in humans

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SOURCE Monash University SYDNEY, July 26, 2018 /PRNewswire/ -- Monash plant scientists have discovered a new molecular mechanism of gene r...

RNA-Dependent Epigenetic Silencing Directs Transcriptional Downregulation Caused by In- tronic Repeat Expansions

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Hannes Eimer, Sridevi Sureshkumar, Avilash Singh Yadav, Calvin Kraupner-Taylor, Champa Bandaranayake, Andrei Seleznev, Tamblyn Thomason, Ste...
Thursday, July 26, 2018

Identification of cardioprotective drugs by medium-scale in vivo pharmacological screening on a Drosophila cardiac model of Friedreich's ataxia

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Amandine Palandri, Elodie Martin, Maria Russi, Michael Rera, Hervé Tricoire, Véronique Monnier; Disease Models & Mechanisms 2018 11: dmm...
Tuesday, July 24, 2018

PTC Therapeutics to Acquire Agilis Biotherapeutics

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Medical Buyer Bureau. July 23, 2018. PTC Therapeutics to Acquire Agilis Biotherapeutics. We are impressed with the clinical results shown ...
Monday, July 23, 2018

Zinc(II) binding on human wild-type ISCU and Met140 variants modulates NFS1 desulfurase activity

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Nicholas G. Fox, Alain Martelli, Joseph F. Nabhan, Jay Janz, Oktawia Borkowska, Christine Bulawa, Wyatt W. Yue, Biochimie, 2018, doi:10.1016...

Genome damage from CRISPR/Cas9 gene editing higher than thought

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ScienceDaily, 19 July 2018. Scientists at the Wellcome Sanger Institute have discovered that CRISPR/Cas9 gene editing can cause greater gene...

Inherited Cardiomyopathies and the Role of Mutations in Non-coding Regions of the Genome

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Salman OF, El-Rayess HM, Abi Khalil C, Nemer G and Refaat MM (2018). Front. Cardiovasc. Med. 5:77. doi: 10.3389/fcvm.2018.00077 Although t...