Saturday, August 17, 2019

Measuring peripheral nerve involvement in Friedreich’s ataxia

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Creigh, P. D., Mountain, J. , Sowden, J. E., Eichinger, K. , Ravina, B. , Larkindale, J. and Herrmann, D. N. (2019). Ann Clin Transl Neurol....

Exicure, Inc.Announced important preclinical data supporting development of SNA technology in the central nervous system (CNS)

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Exicure, Inc. (Nasdaq: XCUR), 8 Aug 2019, pioneer in gene regulatory and immunotherapeutic drugs utilizing spherical nucleic acid (SNA™) co...
Thursday, August 15, 2019

Mitochondrial disorders and drugs: what every physician should know

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Orsucci D, Caldarazzo Ienco E, Siciliano G, Mancuso M.; Drugs in Context 2019; 8: 212588. DOI: 10.7573/dic.212588 In this review we discus...
Wednesday, August 14, 2019

Activators and Inhibitors of NRF2: A Review of Their Potential for Clinical Development

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Natalia Robledinos-Antón, Raquel Fernández-Ginés, Gina Manda, and Antonio Cuadrado, Oxidative Medicine and Cellular Longevity, vol. 2019, Ar...
Tuesday, August 13, 2019

Compassionate use of human recombinant insulin-like growth factor-1 therapy in Friedreich's ataxia

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García Ron A, Rodriguez Mesa M. , Compassionate use of human recombinant insulin-like growth factor-1 therapy in Friedreich's ataxia del...
Sunday, August 11, 2019

Exploring the Potential of Small Molecule-Based Therapeutic Approaches for Targeting Trinucleotide Repeat Disorders

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Arun Kumar Verma & Eshan Khan & Sonali R. Bhagwat & Amit Kumar; Mol Neurobiol (2019). doi:10.1007/s12035-019-01724-4 In recent...
Saturday, August 10, 2019

Excision of the expanded GAA repeats corrects cardiomyopathy phenotypes of iPSC-derived Friedreich's ataxia cardiomyocytes

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Jixue Li, Natalia Rozwadowska, Amanda Clark, Daniel Fil, Jill S. Napierala, Marek Napierala; Stem Cell Research, 2019, 101529, doi:10.1016/j...
Friday, August 9, 2019

Physiologically relevant reconstitution of iron-sulfur cluster biosynthesis uncovers persulfide-processing functions of ferredoxin-2 and frataxin

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Sylvain Gervason, Djabir Larkem, Amir Ben Mansour, Thomas Botzanowski, Christina S. Müller, Ludovic Pecqueur, Gwenaelle Le Pavec, Agnès Dela...
Thursday, August 8, 2019

A Collaborative-Filtering-Based Data Collection Strategy for Friedreich’s Ataxia

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Wenbin Yue, Zidong Wang, Bo Tian, Annette Payne, Xiaohui Liu. Cogn Comput (2019). doi:10.1007/s12559-019-09674-8 We propose a novel data c...
Wednesday, August 7, 2019

Reata gets another shot in Friedreich’s ataxia

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EvaluatePharma. August 06, 2019. Pharmaceuticals will soon find out if its decision to persevere with omaveloxolone despite an earlier fai...