Sunday, September 19, 2021

Microvascular Breakdown Due to Retinal Neurodegeneration in Ataxias

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Christopher A. Turski MD, Gabrielle N. Turski MD, Jennifer Faber MD, Stefan J. Teipel MD, Frank G. Holz MD, Thomas Klockgether MD, Robert P....
Friday, September 17, 2021

The temporal dynamics of the DMN state also correlated with minute-long DMN rsFC

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Naeije G, Coquelet N, Wens V, et al. . Human Brain Mapping. 2021 Sep. DOI: 10.1002/hbm.25621. PMID: 34523778. ; This study demonstrates that...

Blood Neurofilament Light Chain in Genetic Ataxia: A Meta-Analysis

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Peng L, Wang S, Chen Z, Peng Y, Wang C, Long Z, Peng H, Shi Y, Hou X, Lei L, Wan L, Liu M, Zou G, Shen L, Xia K, Qiu R, Tang B, Ashizawa T, ...
Sunday, September 12, 2021

Plasma idebenone monitoring in Friedreich's ataxia patients during a long-term follow-up

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Paredes-Fuentes AJ, Cesar S, Montero R, Latre C, Genovès J, Martorell L, Cuadras D, Colom H, Pineda M, Del Mar O'Callaghan M, Sarquella-...
Wednesday, September 8, 2021

A translational approach to determine target concentrations of MIN-102 (leriglitazone) to support a Phase II study in Friedreich’s ataxia

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S. Poli, L. Rodríguez-Pascau, J. Ros, P. González-Cabo, E. Britti, D. Lynch, G. Pina, S. Pascual, M. Cerrada-Gimenez, D. Eckland, E. Traver,...
Friday, September 3, 2021

Mechanisms of impaired mitochondrial homeostasis and NAD+ metabolism in a model of mitochondrial heart disease exhibiting redox active iron accumulation

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Chiang S, Braidy N, Maleki S, Lal S, Richardson DR, Huang ML.; Redox Biol. 2021 Jun 10;46:102038. doi: 10.1016/j.redox.2021.102038. Epub ahe...
Thursday, September 2, 2021

Retrotope eyes $100m raise for neurodegenerative disease platform

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https://www.clinicaltrialsarena.com   27 Aug 2021 California-based Retrotope aims to expand its investor pool as it prepares to potentially...
Wednesday, September 1, 2021

Determine Range of Tissue Frataxin Concentrations and Other Potential Biomarkers

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ClinicalTrials.gov Identifier: NCT05028764, First Posted : August 31, 2021; Sponsor: Larimar Therapeutics, Inc.  Brief Summary: To examine ...
Sunday, August 29, 2021

Brain Structure and Degeneration Staging in Friedreich Ataxia: MRI Volumetrics from the ENIGMA-Ataxia Working Group

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Harding IH, Chopra S, Arrigoni F, Boesch S, Brunetti A, Cocozza S, Corben LA, Deistung A, Delatycki M, Diciotti S, Dogan I, Evangelisti S, F...
Tuesday, August 24, 2021

Treatment with ROS detoxifying gold quantum clusters alleviates the functional decline in a mouse model of Friedreich ataxia

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CHIARA VILLA, MARIELLA LEGATO, ALESSANDRO UMBACH, CHIARA RIGANTI, REBECCA JONES, BEATRICE MARTINI, MARINA BOIDO, CLAUDIO MEDANA, IRENE FACCH...