Frataxin inhibits the sensitivity of the myocardium to ferroptosis by regulating iron homeostasis

Zhang Z, Jiang W, Zhang C, Yin Y, Mu N, Wang Y, Yu L, Ma H. Frataxin inhibits the sensitivity of the myocardium to ferroptosis by regulating iron homeostasis. Free Radic Biol Med. 2023 Jun 19;205:305-317. doi: 10.1016/j.freeradbiomed.2023.06.016. Epub ahead of print. PMID: 37343689. 

 We showed that regulators of iron metabolism, especially iron regulatory protein activity, were increased in the ischemic myocardium or hypoxia cardiomyocytes. In addition, we found that frataxin, which is involved in iron metabolism, is differentially expressed in the ischemic and reperfused myocardium and involved in the regulation of cardiomyocytes ferroptosis.

Frataxin inhibits the sensitivity of the myocardium to ferroptosis by regulating iron homeostasis