Standing Balance Conditions and Digital Sway Measures for Clinical Trials of Friedreich's Ataxia

Casey, H.L., Shah, V.V., Muzyka, D., McNames, J., El-Gohary, M., Sowalsky, K., Safarpour, D., Carlson-Kuhta, P., Schmahmann, J.D., Rosenthal, L.S., Perlman, S., Rummey, C., Horak, F.B. and Gomez, C.M. (2024), Standing Balance Conditions and Digital Sway Measures for Clinical Trials of Friedreich's Ataxia. Mov Disord. doi:10.1002/mds.29777

 Three of the six standing conditions had completion rates over 70%. Of these three conditions, natural stance and feet together with EO showed the greatest completion rates. All six of the sway measures' mean values were significantly different between FRDA and HC. Four of these six measures discriminated between groups with >0.9 AUC in all three conditions. The Friedreich Ataxia Rating Scale Upright Stability and Total scores correlated with sway measures with P-values

Standing Balance Conditions and Digital Sway Measures for Clinical Trials of Friedreich's Ataxia