RWD132 Onset of Cardiomyopathy and Cardiovascular Disease-Related Burden in Friedreich Ataxia: Real-World Data From Medical Claims

Sheng-Han Kuo, Boyang Bian, Sarah M. England, Daniel R.J. Gomes, Jim McKay, Tony Wang, Robin L. Avila, Susan Perlman, RWD132 Onset of Cardiomyopathy and Cardiovascular Disease-Related Burden in Friedreich Ataxia: Real-World Data From Medical Claims, Value in Health, Volume 28, Issue 6, Supplement 1, 2025, Page S386, ISSN 1098-3015, doi:10.1016/j.jval.2025.04.1715. 

These data show the natural progression of CV events in FA. Our findings demonstrate that patient burden related to progressive CM begins at an early age and that other cardiac disease, particularly arrhythmias and rhythm and heart valve disorders, may begin 2-11 years prior to CM, with CV onset as early as age 7 in the youngest patients. These data have limitations in older populations and those in Medicare but provide previously unavailable data on the onset of CM and CV disease in patients.