Together, these findings implicate cell type specific transcriptional programs as potential drivers of selective vulnerability and establish a framework for prioritising biomarkers in FRDA.
Saturday, March 21, 2026
Friedreich ataxia transcriptomic dysregulation and identification of cell type-specific biomarkers: A systematic review and meta-analysis
Friedreich ataxia transcriptomic dysregulation and identification of cell type-specific biomarkers: A systematic review and meta-analysis
Marnie L Maddock, Sara Miellet, Anjila Dongol, Amy J Hulme, Chloe K Kennedy, Louise A Corben, Rocio K Finol-Urdaneta, Alberto Nettel-Aguirre, Chiara Dionsi, Martin B Delatycki, Joel M Gottesfeld, Massimo Pandolfo, Elisabetta Soragni, Sanjay I Bidichandani, Jarmon G Lees, Shiang Y Lim, Jill S Napierala, Marek Napierala, Mirella Dottori bioRxiv 2026.03.18.712785; doi: 10.64898/2026.03.18.712785
The multifaceted nature of Friedreich ataxia: strategies for comprehensive patient care.
Raza, M. L., Rawalia, M. A., Fatima, Z., & Zehra, H. (2026). The multifaceted nature of Friedreich ataxia: strategies for comprehensive patient care. Neurodegenerative Disease Management, 1–9. doi:10.1080/17582024.2026.2645501
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