Monday, April 6, 2009

Novel insights into iron metabolism by integrating deletome and transcr iptome analysis in an iron deficiency model of the yeast Saccharomyces cerevis

http://www.biomedcentral.com/1471-2164/10/130/abstract

Full text: http://www.biomedcentral.com/content/pdf/1471-2164-10-130.pdf

Novel insights into iron metabolism by integrating deletome and transcr iptome analysis in an iron deficiency model of the yeast Saccharomyces cerevisiae
William J. Jo1,9, Jeung Hyoun Kim1,9, Eric Oh1,9, Daniel Jaramillo2, Patricia Holman1, Alex V. Loguinov1, Adam P. Arkin3,4, Corey Nislow5,6,8, Guri Giaever5, 7, 8 and Chris D. Vulpe 1,10 1 Department of Nutritional Sciences and Toxicology, University of California, Berkeley, California 94720 2 Stanford Genome Technology Center, Stanford University, Palo Alto, California 94304 3 Department of Bioengineering, University of California, Berkeley, California 94720 4 Physical Biosciences Division, Lawrence Berkeley National Laboratory, Berkeley, California 94720 5 University of Toronto, Department of Molecular Genetics, Toronto, Ontario M5S3E1, Canada 6 University of Toronto, Banting and Best Department of Medical Research, Toronto, Ontario M5S3E1, Canada 7University of Toronto, Department of Pharmaceutical Sciences, Toronto, Ontario M5S3E1, Canada 8 University of Toronto, Donnelley Centre for Cellular and Biomolecular Research, Toronto, Ontario M5S3E1, Canada 9 These authors contributed equally on this paper 10 Corresponding author: 119 Morgan Hall, University of California, Berkeley, California 94720, Phone: (510) 642-
1834, Fax: (510) 642-0535 Email addresses: WJJ williamjo@berkeley.edu; JHK jhkim19@berkeley.edu; EO eric_oh@berkeley.edu; DJ nddano@gmail.com; PH ttyholman@yahoo.com; AVL Avl53@aol.com; APA aparkin@lbl.gov; CN corey.nislow@utoronto.ca; GG guri.giaever@utoronto.ca; CDV vulpe@berkeley.edu

Chapter 14 Nucleotide-Dependent Iron-Sulfur Cluster Biogenesis of Endogenous and Imported Apoproteins in Isolated Intact Mitochondria

http://www.sciencedirect.com/science?_ob=ArticleURL&_udi=B7CV2-4W0SP7V-N&_user=10&_rdoc=1&_fmt=&_orig=search&_sort=d&view=c&_acct=C000050221&_version=1&_urlVersion=0&_userid=10&md5=5402f229212062f111307c76b58a5ca2

doi:10.1016/S0076-6879(08)04414-5


Copyright © 2009 Elsevier Inc. All rights reserved.
Chapter 14 Nucleotide-Dependent Iron-Sulfur Cluster Biogenesis of Endogenous and Imported Apoproteins in Isolated Intact Mitochondria
Boominathan Amutha*, Donna M. Gordon‡, Andrew Dancis† and Debkumar Pain*

*Department of Pharmacology and Physiology, UMDNJ, New Jersey Medical School, Newark, New Jersey, USA

†Department of Medicine, Division of Hematology-Oncology, University of Pennsylvania, Philadelphia, Pennsylvania, USA

‡Department of Biological Sciences, Mississippi State University, Mississippi State, Mississippi, USA


Available online 5 April 2009.

Chapter 12 twelve Controlled Expression of Iron-Sulfur Cluster Assembly Components for Respiratory Chain Complexes in Mammalian Cells

http://www.sciencedirect.com/science?_ob=ArticleURL&_udi=B7CV2-4W0SP7V-K&_user=10&_rdoc=1&_fmt=&_orig=search&_sort=d&view=c&_acct=C000050221&_version=1&_urlVersion=0&_userid=10&md5=31b0f067dc11fd11b523136280aa5dc4

doi:10.1016/S0076-6879(08)04412-1


Copyright © 2009 Elsevier Inc. All rights reserved.
Chapter 12 twelve Controlled Expression of Iron-Sulfur Cluster Assembly Components for Respiratory Chain Complexes in Mammalian Cells
Oliver Stehlinga, Alex D. Sheftela and Roland Lilla

aInstitut für Zytobiologie and Zytopathologie, Philipps-Universität, Marburg, Germany


Available online 5 April 2009.




Methods in Enzymology
Volume 456, 2009, Pages 209-231
Mitochondrial Function, Part A: Mitochondrial Electron Transport Complexes and Reactive Oxygen Species

Friday, April 3, 2009

Efficacy of EGb761 in Patients Suffering From Friedreich Ataxia

http://www.clinicaltrials.gov/ct2/show/NCT00824512?term=friedreich

Efficacy of EGb761 in Patients Suffering From Friedreich Ataxia

Rethinking The Genetic Theory Of Inheritance

http://www.sciencedaily.com/releases/2009/01/090118200632.htm

Rethinking The Genetic Theory Of Inheritance

An advance online publication of this study will be available on the Nature Genetics website on January 18, 2009.
Adapted from materials provided by Centre for Addiction and Mental Health, via EurekAlert!, a service of AAAS

Efficient gene delivery to the adult and fetal CNS using pseudotyped non-integrating lentiviral vectors

http://www.nature.com/gt/journal/vaop/ncurrent/abs/gt2008186a.html
Efficient gene delivery to the adult and fetal CNS using pseudotyped non-integrating lentiviral vectors
A Rahim1,2,3, A M S Wong4, S J Howe2, S M K Buckley3, A D Acosta-Saltos1, K E Elston4, N J Ward2, N J Philpott2, J D Cooper4, P N Anderson5, S N Waddington3, A J Thrasher2,6 and G Raivich1,5
1Perinatal Brain Protection and Repair Group, Department of Obstetrics and Gynaecology, University College London, London, UK
2Molecular Immunology Unit, Centre for Immunodeficiency, Institute of Child Health, University College London, London, UK
3Department of Haematology, Haemophilia Centre and Haemostasis Unit, Royal Free and University College Medical School, London, UK
4Pediatric Storage Disorders Laboratory, Department of Neuroscience, Institute of Psychiatry, Kings College London, London, UK
5Department of Anatomy and Developmental Biology, University College London, London, UK
6Great Ormond Street Hospital NHS Trust, London, UK
Correspondence: Dr AJ Thrasher, Molecular Immunology Unit, Centre for Immunodeficiency, Institute of Child Health, 30 Guilford Street, London WC1N 1EH, UK. E-mail: a.thrasher@ich.ucl.ac.uk
Received 12 June 2008; Revised 2 December 2008; Accepted 3 December 2008; Published online 22 January 2009.

Lateral-flow immunoassay for detecting drug-induced inhibition of mitochondrial DNA replication and mtDNA-encoded protein synthesis.

http://www.ncbi.nlm.nih.gov/pubmed/19152798?dopt=Abstract


Lateral-flow immunoassay for detecting drug-induced inhibition of mitochondrial DNA replication and mtDNA-encoded protein synthesis.

Nadanaciva S, Willis JH, Barker ML, Gharaibeh D, Capaldi RA, Marusich MF, Will Y.

MitoSciences Inc., 1850 Millrace Drive, Eugene, OR 97403, United States.

Impaired Nuclear Nrf2 Translocation Undermines the Oxidative Stress Response in Friedreich Ataxia

http://www.plosone.org/article/info%3Adoi%2F10.1371%2Fjournal.pone.0004253



Impaired Nuclear Nrf2 Translocation Undermines the Oxidative Stress Response in Friedreich Ataxia
Vincent Paupe1,2, Emmanuel P. Dassa1,2, Sergio Goncalves1,2, Françoise Auchère3, Maria Lönn4, Arne Holmgren4, Pierre Rustin1,2*
1 Inserm, U676, Hôpital Robert Debré, Bât. Ecran, Paris, France, 2 Faculté de médecine Denis Diderot, IFR02, Université Paris 7, Laboratoire d'Ingénierie des Protéines et Contrôle Métabolique, Paris, France, 3 Département de Biologie des Génomes, Institut Jacques Monod (UMR 7592 CNRS - Universités Paris 6 & 7), Paris, France, 4 Medical Nobel Institute for Biochemistry, Department of Medical Biochemistry and Biophysics Karolinska Institutet, Stockholm, Sweden

Prevalence of hereditary ataxia and spastic paraplegia in southeast Norway: a population-based study.

http://www.ncbi.nlm.nih.gov/pubmed/19339254?dopt=Abstract

Brain. 2009 Mar 31. [Epub ahead of print]
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Prevalence of hereditary ataxia and spastic paraplegia in southeast Norway: a population-based study.

Erichsen AK, Koht J, Stray-Pedersen A, Abdelnoor M, Tallaksen CM.

1 Department of Neurology, Ullevål University Hospital, Oslo, Norway.

]

Rewrite The Textbooks: Transcription Is Bidirectional

http://www.sciencedaily.com/releases/2009/01/090125142123.htm

Rewrite The Textbooks: Transcription Is Bidirectional