First half report 2010 - Lundbeck

Lu AA24493 is in clinical phase II in the treatment of Friedreich's ataxia and
in clinical phase I in the treatment of acute ischaemic stroke. Ongoing studies
in both programmes are expected to be concluded in the second half of 2010.

Santhera Obtains European Patent for Use of Catena®/Sovrima®

Liestal, Switzerland, August 13, 2010 - Santhera Pharmaceuticals (SIX: SANN)
announced today that the European Patent Office granted patent protection for
the use of idebenone (brand name Catena®/Sovrima®) in the treatment of Duchenne
Muscular Dystrophy and other muscular dystrophies.

Friedreich’s Ataxia Induced Pluripotent Stem Cells Recapitulate GAA•TTC Triplet-Repeat Instability

NCBI, Public on Jul 02, 2010

Experiment type: Expression profiling by array

Keywords: Friedreich’s ataxia (FRDA), GAA•TTC trinucleotide repeats, FXN gene, induced pluripotent stem cells (iPSCs), fibroblasts, retroviral transduction, Msh2, repeat instability.

A Phase 3, Double-blind, Placebo-Controlled Trial of Idebenone in Friedreich Ataxia

Arch Neurol. 2010;67(8):941-947. doi:10.1001/archneurol.2010.168

David R. Lynch, MD, PhD; Susan L. Perlman, MD; Thomas Meier, PhD  

 

Automated quantitative gait analysis in animal models of movement disorders

BMC Neuroscience 2010, 11:92doi:10.1186/1471-2202-11-92

Caroline Vandeputte, Jean-Marc Taymans, Cindy Casteels, Frea Coun, Yicheng Ni, Koen Van Laere and Veerle Baekelandt.

OPEN ACCESS

Conclusion

The automated quantitative gait analysis test may be a useful tool to study both motor impairment and recovery associated with various neurological motor disorders.

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Erythropoiesis and iron sulfur cluster biogenesis

Advances in Hematology, Received 1 March 2010; Revised 4 June 2010; Accepted 2 August 2010

Hong Ye and Tracey A. Rouault

OPEN ACCES

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Aluminum induces neurodegeneration and its toxicity arises from increased iron accumulation and reactive oxygen species (ROS) production.

Neurobiol Aging. 2010 Jul 29.

Wu Z, Du Y, Xue H, Wu Y, Zhou B.
State Key Laboratory of Biomembrane and Membrane Biotechnology, School of Life Sciences, Tsinghua University, Beijing 100084, China.

I would like to emphasize: .../... "suggesting Friedreich's ataxia patients might be more susceptible to Al toxicity".../...

A rapid, noninvasive immunoassay for frataxin: Utility in assessment of Friedreich ataxia.

Mol Genet Metab. 2010 Jul 8. [Epub ahead of print]

Deutsch EC, Santani AB, Perlman SL, Farmer JM, Stolle CA, Marusich MF, Lynch DR.
Department of Pharmacology, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA.

Keywords: Friedreich ataxia (FRDA), frataxin, Western blot analysis, fibroblasts, lymphocytes, , muscle biopsies, lateral flow immunoassay, buccal cells.

Current and emerging treatment options in the management of Friedreich ataxia

Neuropsychiatric Disease and Treatment, Published Date July 2010 , Volume 2010:6 Pages 491 - 499

Michelangelo Mancuso, Daniele Orsucci, Anna Choub, Gabriele Siciliano
Department of Neuroscience, Neurological Clinic, University of Pisa, Pisa, Italy

Keywords: Friedreich ataxia (FRDA), Oxidative damage, mitochondria, antioxidant protection, idebenone, cardiac hypertrophy, frataxin gene transcription, iron-chelating therapies, erythropoietin, histone deacetylase inhibitors, gene-based strategies.

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EMBL scientists identify proteins that ensure iron balance

EurekAlert, Public release date: 4-Aug-2010