Structural bases for the interaction of frataxin with the central components of iron–sulphur cluster assembly

Nature Communications, Volume:1, Article number: 95, DOI: doi:10.1038/ncomms1097
Received 08 June 2010, Accepted 22 September 2010, Published 19 October 2010

National Institute for Medical Research, The Ridgeway, London NW7 1AA, UK.
* Filippo Prischi,
* Clara Iannuzzi,
* Chiara Pastore,
* Salvatore Adinolfi,
* Stephen R. Martin &
* Annalisa Pastore
European Molecular Biology Laboratory, EMBL c/o DESY, Notkestrasse 85, Hamburg D-22603, Germany.
* Petr V. Konarev &
* Dmitri I. Svergun

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Mitochondrial ROS Generation and Its Regulation: Mechanisms Involved in H2O2 Signaling

Antioxidants & Redox Signaling. Online Ahead of Print: October 18, 2010, doi:10.1089/ars.2010.3363.
Michel Rigoulet, Edgar D. Yoboue, Anne Devin. Université Bordeaux 2, and Institute of Biochemistry and Genetics of the Cell (IBGC) du CNRS, Bordeaux, France.

Keyworsd: Mitochondria, reactive oxygen species, oxidative stress, respiratory chain, dehydrogenases, bc1 complex, complex I, signaling molecules.

Public summary of opinion on orphan designationN-(6-(2-aminophenylamino)-6-oxohexyl)-4-methylbenzamide for the treatment of Friedreich’s ataxia,

12 October 2010
EMA/COMP/455242/2010
Committee for Orphan Medicinal Products.

On 1 October 2010, orphan designation (EU/3/10/793) was granted by the European Commission to Repligen Europe Limited, Ireland, for N-(6-(2-aminophenylamino)-6-oxohexyl)-4-methylbenzamide for the treatment of Friedreich’s ataxia.

Induced pluripotency: history, mechanisms, and applications

Genes & Dev. 2010. 24: 2239-2263, doi: 10.1101/gad.1963910
Matthias Stadtfeld, Konrad Hochedlinger

(REVIEWS)

OPEN ACCESS

The generation of induced pluripotent stem cells (iPSCs) from somatic cells demonstrated that adult mammalian cells can be reprogrammed to a pluripotent state by the enforced expression of a few embryonic transcription factors.

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In vivo evidence for the iron binding activity of an iron-sulfur cluster assembly protein IscA in Escherichia co

Biochem. J. (2010) Immediate Publication, doi:10.1042/BJ20101507

Wu Wang, Hao Huang, Guoqiang Tan, Fan Si, Min Liu, Aaron P. Landry, Jianxin Lu and Huangen Ding
Biological Sciences, Louisiana State University, Baton Rouge, LA 70803, U.S.A.

"IscU, a proposed iron-sulfur cluster assembly scaffold protein, and CyaY, a bacterial frataxin homolog that has been postulated as an iron donor for the iron-sulfur cluster assembly, fail to bind any iron in E. coli cells under the same experimental conditions"

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Epigenetic modifications and human disease

Nature Biotechnology, Volume:28, Pages:1057–1068,Year published:(2010)
DOI:10.1038/nbt.1685, Published online 13 October 2010

Anna Portela & Manel Esteller
Cancer Epigenetics and Biology Program (PEBC), Bellvitge Biomedical Research Institute (IDIBELL), Barcelona, Catalonia, Spain.
Manel Esteller
Institucio Catalana de Recerca i Estudis Avançats (ICREA), Barcelona, Catalonia, Spain.

Epigenetic modifications in neurodegenerative and neurological diseases (Friedreich's ataxia) , Epigenetic modifications in neurodevelopmental disorder

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Epigenetic modifications as therapeutic targets

Nature Biotechnology, Volume: 28 ,Pages: 1069–1078,Year published:(2010)
DOI:10.1038/nbt.1678, Published online 13 October 2010

Theresa K Kelly, Daniel D De Carvalho & Peter A Jones Departments of Urology and Biochemistry and Molecular Biology, Norris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California, Los Angeles, California, USA.

The paper focus on recent examples in which epigenetic modifications have been used to evaluate disease risk, progression and clinical response. It provide a broad overview of the accomplishments, remaining challenges and unrealized potential of epigenetic therapies in a range of diseases, with a particular emphasis on cancer.

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On the Trail of the Epigenetic Code: Test System on Drosophila Should Provide the Key to Histone Function

ScienceDaily (Oct. 12, 2010) — Test system on Drosophila should provide the key to histone function. The genetic inherited material DNA was long viewed as the sole bearer of hereditary information. The function of its packaging proteins, the histones, was believed to be exclusively structural. Additional genetic information can be stored, however, and passed on to subsequent generations through chemical changes in the DNA or histones. read more

Original paper: A genetic system to assess in vivo the functions of histones and histone modifications in higher eukaryotes

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Kinematic analysis of lingual movements during consonant productions in dysarthric speakers with Friedreich's ataxia: A case-by-case analysis.

Clin Linguist Phon. 2010 Oct 8. [Epub ahead of print]

Folker JE, Murdoch BE, Cahill LM, Delatycki MB, Corben LA, Vogel AP.

School of Health and Rehabilitation Sciences, The University of Queensland, Brisbane, QLD, Australia.

An in Vivo Method for Characterization of Protein Interactions within Sulfur Trafficking Systems of E. coli

J. Proteome Res., Just Accepted Manuscript, DOI: 10.1021/pr100920r
Publication Date (Web): October 11, 2010

Heather May Bolstad and Matthew James Wood

KEYWORDS: iron-sulfur clusters, in vivo method, mass spectrometry, iron-sulfur biogenesis, general tool for the determination of sulfur trafficking mechanisms.

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