Effects of Erythropoietin on Endothelial Progenitor Cells, Frataxin Levels and Oxidative Metabolism in the Skeletal Muscle of Friedreich Ataxia Patients

AAN 2010 - American Academy of Neurology?

Wolfgang Nachbauer, Julia Wanschitz, Markus Reindl, Innsbruck, Austria, Barbara Scheiber-Mojdehkar, Vienna, Austria, Werner Poewe, Sylvia Boesch, Innsbruck, Austria

STATegics, Inc. Announces Award from the Department of Defense to Advance Proprietary Small Molecule Mimetics of Erythropoietin for the Treatment of Traumatic Brain Injury

SUNNYVALE, Calif., Nov. 16, 2010 (GLOBE NEWSWIRE)
STATegics' programs have been supported by grants from the National Institute of Neurological Disorders and Stroke (NINDS), Friedreich's Ataxia Research Alliance (FARA) and the U.S. Government's Qualifying Therapeutic Discovery Project (QTDP) program.

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The lead indication for the erythropoietin mimetics is Friedreich's ataxia,
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Whole-body vibration alters blood flow velocity and neuromuscular activity in Friedreich’s ataxia

Clinical Physiology and Functional Imaging, no. doi: 10.1111/j.1475-097X.2010.00992.x
Herrero, A. J., Martín, J., Martín, T., García-López, D., Garatachea, N., Jiménez, B. and Marín, P. J.

Keywords: Doppler ultrasound, electromyography, oscillating platform, rate of perceived exertion, rehabilitation, vibration frequency.

Re-Engineering Erythropoietin as an IgG Fusion Protein That Penetrates the Blood−Brain Barrier in the Mouse

Mol. Pharmaceutics, Article ASAP, DOI: 10.1021/mp1001763

 

Qing-Hui Zhou^†, Ruben J. Boado^†‡, Jeff Zhiqiang Lu^‡, Eric Ka-Wai Hui^‡, and William M. Pardridge*^†

Department of Medicine, UCLA, Los Angeles, California 90024, United States, and ArmaGen Technologies, Inc., Santa Monica, California 90401, United States

 

Keywords: drug targeting; drug delivery; Erythropoietin (EPO),  neuroprotective agent,  blood−brain barrier (BBB), chimeric monoclonal antibody (mAb),  transferrin receptor (TfR),  cTfRMAb-EPO, fusion protein,  IgG fusion protein,

 

DockAnalyse: an application for the analysis of protein-protein interactions

BMC Structural Biology 2010, 10:37doi:10.1186/1472-6807-10-37

Isaac Amela , Pedro Delicado , Antonio Gomez , Silvia Bonas , Enrique Querol and Juan Cedano

Institut de Biotecnologia i de Biomedicina Parc de Recerca UAB and Departament de Bioquímica i Biologia Molecular, Universitat Autònoma de Barcelona. 08193-Bellaterra, Barcelona, Spain
Departament d’Estadística i Investigació Operativa, Universitat Politècnica de Catalunya. 08034-Barcelona, Spain.

OPEN ACCESS

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Most of the studies prompt the suggestion that the iron and sulfur atoms required for the ISC biogenesis on Isu1/Isu2 are donated by other proteins, named Frataxin and Nfs1 [20]. This ISC biogenesis machinery is not yet well understood and problems in it cause several human diseases linked to protein/enzyme deficits.

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Iron-Sulfur Clusters: Biogenesis, Molecular Mechanisms and Their Functional Significance

Iron-Sulfur Clusters: Biogenesis, Molecular Mechanisms and Their Functional Significance

Xiang Ming Xu, Simon Geir Møller. Antioxidants & Redox Signaling. -Not available-, ahead of print. doi:10.1089/ars.2010.3259.

Keywords:Iron-sulfur clusters [Fe-S], inorganic cofactors, regulation of enzyme activity, mitochondrial respiration, ribosome biogenesis, cofactor biogenesis, gene expression regulation, nucleotide metabolism, mitochondria, human diseases.

Spectral measures of the effects of Friedreich's ataxia on speech.

Int J Speech Lang Pathol. 2010 Nov 9. [Epub ahead of print]

Rosen KM, Folker JE, Murdoch BE, Vogel AP, Cahill LM, Delatycki MB, Corben LA.
The University of Queensland, Brisbane, Australia.

Keywords:Friedreich's ataxia (FRDA), speech motor control, dysarthria, ,speaking task, spectral variation.

Epoetin alfa increases frataxin production in Friedreich's ataxia without affecting hematocrit†

Saccà, F., Piro, R., De Michele, G., Acquaviva, F., Antenora, A., Carlomagno, G., Cocozza, S., Denaro, A., Guacci, A., Marsili, A., Perrotta, G., Puorro, G., Cittadini, A. and Filla, A. , Epoetin alfa increases frataxin production in Friedreich's ataxia without affecting hematocrit. Movement Disorders, n/a. doi: 10.1002/mds.23435

Tags: efficacy, safety, and tolerability, two single doses of Epoetin alfa, Friedreich's ataxia, subcutaneously, frataxin, did not affect hematocrit, cardiac function, and neurological scale, phlebotomy, lack of erythropoietic effect.

The benefits and limitations of animal models for translational research in neurodegenerative diseases

Nature Medicine 16, 1210 - 1214 (2010), doi:10.1038/nm.2224

Mathias Jucker is at the Department of Cellular Neurology, Hertie Institute for Clinical Brain Research, University of Tübingen, and the DZNE-German Center for Neurodegenerative Diseases, Tübingen, Germany.

The Herrenhausen Symposium on Neurodegeneration

Nature Medicine 16, 1200 (2010), Published online: 4 November 2010 | doi:10.1038/nm1110-1200

Although the pathological hallmarks of neurodegenerative diseases have been described for over 100 years, our understanding of the molecular events leading to neuronal death has emerged over the past two decades. Despite all of this progress in basic research, why do we still lack disease-modifying therapeutics?