PLOS Biology, Dec 14, 2010 (publication date)
Ricardo Pires das Neves1,2,3, Nick S. Jones4, Lorena Andreu1, Rajeev Gupta1, Tariq Enver1, Francisco J. Iborra1,5*
1 Medical Research Council Molecular Haematology Unit, Weatherall Institute of Molecular Medicine, John Radcliffe Hospital, Oxford, United Kingdom, 2 Biocant Center of Innovation and Biotechnology, Cantanhede, Portugal, 3 Center for Neuroscience and Cell Biology University of Coimbra, Coimbra, Portugal, 4 Department of Physics and Biochemistry, Oxford Centre for Integrative Systems Biology, CABDyN Complexity Centre, Oxford, United Kingdom, 5 Department of Molecular and Cellular Biology, Centro Nacional de Biotecnología, Consejo Superior de Investigaciones Científicas, Madrid, Spain
FULL TEXT PDF
Thursday, December 16, 2010
A Decrementing Form of Plasticity Apparent in Cerebellar Learning
The Journal of Neuroscience, December 15, 2010, 30(50):16993-17003; doi:10.1523/JNEUROSCI.2455-10.2010
Tatsuya Ohyama,1 Horatiu Voicu,3 Brian Kalmbach,1 and Michael D. Mauk1,2
1Center for Learning and Memory and 2Section of Neurobiology, The University of Texas at Austin, Austin, Texas 78712-0805, and 3Department of Neurobiology and Anatomy, The University of Texas-Houston Health Science Center, Houston, Texas 77030
" These results demonstrate the utility of eyelid conditioning as a means to identify and characterize the rules that govern input to output transformations in the cerebellum."
Tatsuya Ohyama,1 Horatiu Voicu,3 Brian Kalmbach,1 and Michael D. Mauk1,2
1Center for Learning and Memory and 2Section of Neurobiology, The University of Texas at Austin, Austin, Texas 78712-0805, and 3Department of Neurobiology and Anatomy, The University of Texas-Houston Health Science Center, Houston, Texas 77030
" These results demonstrate the utility of eyelid conditioning as a means to identify and characterize the rules that govern input to output transformations in the cerebellum."
Wednesday, December 15, 2010
The value of Arabidopsis research in understanding human disease states.
Curr Opin Biotechnol. 2010 Dec 6.
Xu XM, Møller SG.
Centre for Organelle Research, Faculty of Science and Technology, University of Stavanger, Norway.
Keywords: Arabidopsis thaliana, understand molecular mechanisms, human disease, neurodegenerative disorders, Alzheimer's, Parkinson's, Friedreich Ataxia.
Xu XM, Møller SG.
Centre for Organelle Research, Faculty of Science and Technology, University of Stavanger, Norway.
Keywords: Arabidopsis thaliana, understand molecular mechanisms, human disease, neurodegenerative disorders, Alzheimer's, Parkinson's, Friedreich Ataxia.
Tuesday, December 14, 2010
Blood cells from Friedreich ataxia patients harbor frataxin deficiency without a loss of mitochondrial function
Mitochondrion, Article in Press, Accepted Manuscript, doi:10.1016/j.mito.2010.12.003
Mary A. Selak a, Elise Lyver b, Elizabeth Micklow b, Eric C. Deutsch c, Ozlem Onder d, Nur Selamoglu d, Claire Yager a, Simon Knight b, Martin Carroll b, Fevzi Daldal d, Andrew Dancis b, David R. Lynch c and Jean-Emmanuel Sarry b,
a Children's Hospital of Philadelphia Research Institute, Children's Hospital of Philadelphia and University of Pennsylvania, Philadelphia, PA, USA
b Division of Hematology/Oncology, University of Pennsylvania School of Medicine, Philadelphia, PA, USA
c Departments of Neurology and Pediatrics, University of Pennsylvania School of Medicine, and Children's Hospital of Philadelphia, Philadelphia, PA, USA
d Department of Biology, University of Pennsylvania, Philadelphia, PA, USA
KEYWORDS: Friedreich ataxia (FRDA), frataxin, neurons, cardiomyocytes, platelets, peripheral blood mononuclear cells, mitochondria, biomarkers.
Mary A. Selak a, Elise Lyver b, Elizabeth Micklow b, Eric C. Deutsch c, Ozlem Onder d, Nur Selamoglu d, Claire Yager a, Simon Knight b, Martin Carroll b, Fevzi Daldal d, Andrew Dancis b, David R. Lynch c and Jean-Emmanuel Sarry b,
a Children's Hospital of Philadelphia Research Institute, Children's Hospital of Philadelphia and University of Pennsylvania, Philadelphia, PA, USA
b Division of Hematology/Oncology, University of Pennsylvania School of Medicine, Philadelphia, PA, USA
c Departments of Neurology and Pediatrics, University of Pennsylvania School of Medicine, and Children's Hospital of Philadelphia, Philadelphia, PA, USA
d Department of Biology, University of Pennsylvania, Philadelphia, PA, USA
KEYWORDS: Friedreich ataxia (FRDA), frataxin, neurons, cardiomyocytes, platelets, peripheral blood mononuclear cells, mitochondria, biomarkers.
Restless legs syndrome in Friedreich ataxia: A polysomnographic study
Movement Disorders, n/a. doi: 10.1002/mds.22769 (Early View (Articles online in advance of print)
Frauscher, B., Hering, S., Högl, B., Gschliesser, V., Ulmer, H., Poewe, W. and Boesch, S. M.
Keywords: sleep disturbance, restless legs syndrome, Friedreich ataxia, Frataxin, ferritin, periodic leg movements, polysomnography.
Frauscher, B., Hering, S., Högl, B., Gschliesser, V., Ulmer, H., Poewe, W. and Boesch, S. M.
Keywords: sleep disturbance, restless legs syndrome, Friedreich ataxia, Frataxin, ferritin, periodic leg movements, polysomnography.
Sunday, December 12, 2010
US reviews human trial participant protections
The Lancet, Volume 376, Issue 9757, Pages 1975 - 1976, 11 December 2010, doi:10.1016/S0140-6736(10)62247-7
Nellie Bristol
Commission Chair Amy Gutmann, President of the University of Pennsylvania stated. “We have an ethical obligation to protect the health and well-being of all research participants.”
Nellie Bristol
Commission Chair Amy Gutmann, President of the University of Pennsylvania stated. “We have an ethical obligation to protect the health and well-being of all research participants.”
Thursday, December 9, 2010
Electrophysiology of Respiratory Chain Complexes and the ADP-ATP Exchanger in Native Mitochondrial Membranes.
Biochemistry. 2010 Dec 7;49(48):10308-18. Epub 2010 Nov 11.
Watzke N, Diekert K, Obrdlik P.
IonGate Biosciences GmbH, Industriepark Hoechst, D528, 65926 Frankfurt am Main, Germany.
Keywords: mitochondrial membranes, proton-pumping respiratory chain complexes, mitochondrial secondary active solute transport proteins, solid-supported membrane (SSM) technology, respiratory chain complexes CI, CII, CIII, and CIV, the F(O)F(1)-ATPase/synthase (CV), the adenine nucleotide translocase (ANT), oxidative phosphorylation (OXPHOS), uncoupler carbonyl cyanide m-chlorophenylhydrazone (CCCP), IC(50), Coenzyme Q (CoQ), decylubiquinone (DBQ), idebenone (Ide).
Watzke N, Diekert K, Obrdlik P.
IonGate Biosciences GmbH, Industriepark Hoechst, D528, 65926 Frankfurt am Main, Germany.
Keywords: mitochondrial membranes, proton-pumping respiratory chain complexes, mitochondrial secondary active solute transport proteins, solid-supported membrane (SSM) technology, respiratory chain complexes CI, CII, CIII, and CIV, the F(O)F(1)-ATPase/synthase (CV), the adenine nucleotide translocase (ANT), oxidative phosphorylation (OXPHOS), uncoupler carbonyl cyanide m-chlorophenylhydrazone (CCCP), IC(50), Coenzyme Q (CoQ), decylubiquinone (DBQ), idebenone (Ide).
Wednesday, December 8, 2010
Axial diffusivity is increased in the degenerating superior cerebellar peduncles of Friedreich's ataxia.
Neuroradiology. 2010 Dec 3. [Epub ahead of print]
Della Nave R, Ginestroni A, Diciotti S, Salvatore E, Soricelli A, Mascalchi M., S. Giuseppe Hospital, Radiodiagnostic Section, Empoli, Italy.
Keywords: Decreased fractional anisotropy (FA), diffusion tensor MR imaging (DTI), white matter (WM), radial diffusivity, axial diffusivity, Friedreich's ataxia (FRDA), selective neuronal loss, dentate nuclei, cerebellar peduncles (SCPs), TBSS analysis.
Della Nave R, Ginestroni A, Diciotti S, Salvatore E, Soricelli A, Mascalchi M., S. Giuseppe Hospital, Radiodiagnostic Section, Empoli, Italy.
Keywords: Decreased fractional anisotropy (FA), diffusion tensor MR imaging (DTI), white matter (WM), radial diffusivity, axial diffusivity, Friedreich's ataxia (FRDA), selective neuronal loss, dentate nuclei, cerebellar peduncles (SCPs), TBSS analysis.
Tuesday, December 7, 2010
Large-scale in silico modeling of metabolic interactions between cell types in the human brain
Nature Biotechnology, Year published:(2010), DOI: doi:10.1038/nbt.1711
Nathan E Lewis, Gunnar Schramm, Aarash Bordbar, Jan Schellenberger, Michael P Andersen, Jeffrey K Cheng, Nilam Patel, Alex Yee, Randall A Lewis, Roland Eils, Rainer König, Bernhard Ø Palsson.
Keywords: Metabolic interactions, gene expression data, proteomics data, literature-based manual curation, model human metabolism, metabolites, interstitial fluid, models of brain energy metabolism, astrocytes, Alzheimer's disease, regions of the brain.
Simplest explanation: Metabolism Models May Explain Why Alzheimer's Disease Kills Some Neuron Types First (ScienceDaily (Dec. 6, 2010)
Nathan E Lewis, Gunnar Schramm, Aarash Bordbar, Jan Schellenberger, Michael P Andersen, Jeffrey K Cheng, Nilam Patel, Alex Yee, Randall A Lewis, Roland Eils, Rainer König, Bernhard Ø Palsson.
Keywords: Metabolic interactions, gene expression data, proteomics data, literature-based manual curation, model human metabolism, metabolites, interstitial fluid, models of brain energy metabolism, astrocytes, Alzheimer's disease, regions of the brain.
Simplest explanation: Metabolism Models May Explain Why Alzheimer's Disease Kills Some Neuron Types First (ScienceDaily (Dec. 6, 2010)
Monday, December 6, 2010
Taking the lottery out of gene therapy
NEW SCIENTIST HEALTH ,Magazine issue 2789
GENE therapy should become a more exact science thanks to the discovery that it is possible to predict where a transferred gene is likely to be inserted into the recipient's DNA.
"Peter Cherepanov at Imperial College London, who was not part of the team, says now that the probability of an undesirable insertion can be estimated, it will become easier to balance the chance of success with the risk of side effects."
ORIGINAL PAPER: Deciphering the Code for Retroviral Integration Target Site Selection
FULL TEXT PDF
GENE therapy should become a more exact science thanks to the discovery that it is possible to predict where a transferred gene is likely to be inserted into the recipient's DNA.
"Peter Cherepanov at Imperial College London, who was not part of the team, says now that the probability of an undesirable insertion can be estimated, it will become easier to balance the chance of success with the risk of side effects."
ORIGINAL PAPER: Deciphering the Code for Retroviral Integration Target Site Selection
FULL TEXT PDF
Subscribe to:
Posts (Atom)
