Reata Announces the Initiation of Phase 2 Studies Examining RTA 408 for the Treatment of Friedreich's Ataxia and Mitochondrial Myopathies

Reata Announces the Initiation of Phase 2 Studies Examining RTA 408 for the Treatment of Friedreich's Ataxia and Mitochondrial Myopathies. -(Marketwired - September 30, 2014), SOURCE: Reata Pharmaceuticals, Inc.

The two initial Phase 2 trials will both be multi-center, double-blind, randomized, dose-ranging, placebo-controlled studies.

Comparing speech characteristics in spinocerebellar ataxias type 3 and type 6 with Friedreich ataxia

Comparing speech characteristics in spinocerebellar ataxias type 3 and type 6 with Friedreich ataxia. Bettina Brendel, Matthis Synofzik, Hermann Ackermann, Tobias Lindig, Theresa Schölderle, Ludger Schöls, Wolfram Ziegler; Journal of Neurology, September 2014. DOI 10.1007/s00415-014-7511-8

Idebenone and neuroprotection: antioxidant, pro-oxidant, or electron carrier?

Idebenone and neuroprotection: antioxidant, pro-oxidant, or electron carrier?. Sausan Jaber, Brian M. Polster; Journal of Bioenergetics and Biomembranes
September 2014 DOI 10.1007/s10863-014-9571-y

A Novel Mouse Model for Friedreich's Ataxia

A Novel Mouse Model for Friedreich's Ataxia. Inventors: Geschwind, Daniel H.; UCLA Office of Intellectual Property & Industry Sponsored Research

This new model exhibits various symptoms observed in FRDA patients, including cardiac atrophy, elevated iron-responsive proteins, neurodegeneration, motor neuropathy–and for the first time in an FRDA model–scoliosis and ataxia.

Next-Generation R&D Partnerships: The NCATS Success Story

Next-Generation R&D Partnerships: The NCATS Success Story , Information Technology and Innovation Foundation.

Free event on Wednesday, October 29, 2014,10:00 AM - 11:30 AM, Rayburn House Office Building 45 Independence Ave SW
(2168) Washington, DC20515

FGF8 Activates Proliferation and Migration in Mouse Post-Natal Oligodendrocyte Progenitor Cells

FGF8 Activates Proliferation and Migration in Mouse Post-Natal Oligodendrocyte Progenitor Cells . Pablo Cruz-Martinez, Almudena Martinez-Ferre, Jesus Jaramillo-Merchán, Alicia Estirado, Salvador Martinez, Jonathan Jones; PLoS ONE 9(9): e108241. doi:10.1371/journal.pone.0108241

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FA Dyclonine Study Review

FA Dyclonine Study Review. Posted: Sep 19 2014, By: Robert Dean

Understanding the frustration arising from the competition between function, misfolding, and aggregation in a globular protein.

Understanding the frustration arising from the competition between function, misfolding, and aggregation in a globular protein. Gianni S, Camilloni C, Giri R, Toto A, Bonetti D, Morrone A, Sormanni P, Brunori M, Vendruscolo M. Proc Natl Acad Sci U S A. 2014 Sep 16. pii: 201405233. [Epub ahead of print]

R2* mapping for brain iron: Associations with cognition in normal aging

R2* mapping for brain iron: Associations with cognition in normal aging; Christine Ghadery, Lukas Pirpamer, Edith Hofer, Christian Langkammer, Katja Petrovic, Marisa Loitfelder, Petra Schwingenschuh, Stephan Seiler, Marco Duering, Eric Jouvent, Helena Schmidt, Franz Fazekas, Jean-Francois Mangin, Hugues Chabriat, Martin Dichgans, Stefan Ropele, Reinhold Schmidt; Neurobiology of Aging, Available online 19 September 2014, ISSN 0197-4580, http://dx.doi.org/10.1016/j.neurobiolaging.2014.09.013.

We found the highest iron concentration in the globus pallidus, and pallidal as well as putaminal iron was significantly and inversely associated with cognitive performance in all cognitive domains, except memory. These associations were iron load-dependent. Vascular brain lesions and brain volume did not mediate the relationship between iron and cognitive performance.

Overlapping Binding Sites of the Frataxin Homologue Assembly Factor and the Heat Shock Protein 70 Transfer Factor on the Isu Iron-sulfur Cluster Scaffold Protein

Overlapping Binding Sites of the Frataxin Homologue Assembly Factor and the Heat Shock Protein 70 Transfer Factor on the Isu Iron-sulfur Cluster Scaffold Protein . Mateusz Manicki, Julia Majewska, Szymon Ciesielski, Brenda Schilke, Anna Blenska, Jacek Kominek, Jaroslaw Marszalek, Elizabeth A. Craig, and Rafal Dutkiewicz; J. Biol. Chem. jbc.M114.596726. First Published on September 16, 2014, doi:10.1074/jbc.M114.596726

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