Combined Therapy with Idebenone and Deferiprone in Patients with Friedreich's Ataxia.

Cerebellum. 2010 Sep 24.

Velasco-Sánchez D, Aracil A, Montero R, Mas A, Jiménez L, O'Callaghan M, Tondo M, Capdevila A, Blanch J, Artuch R, Pineda M.

Cardiology Department, Sant Joan de Déu Hospital and the University of Barcelona, 2, Passeig Sant Joan de Déu, 08950 Esplugues, Barcelona, Spain

KEYWORDS: Iron chelators,Friedreich's ataxia, mitochondrial iron pools, neurological signs, cardiac function parameters, prospective open-label single-arm study, idebenone (20 mg/kg/day), deferiprone (20 mg/kg/day), International Cooperative Ataxia Rating Scale (ICARS) scores, echocardiographic measurements, MRI (magnetic resonance imaging) techniques, neutropenia, progressive reduction of plasma iron parameters.