Friedreich’s ataxia treatment’s sexual dimorphism

Ferreira, J. Friedreich’s ataxia treatment’s sexual dimorphism. Lab Anim 54, 75 (2025). doi:10.1038/s41684-025-01535-2 

While NRF2 activation was confirmed in males, no motor or sensory improvements were observed compared to wildtype animals. Female TG+ mice showed no response to the drugs, revealing sexual dimorphism in NRF2 signaling. These results identify early sexual dimorphism in response to treatment and highlight the limitations of NRF2 therapies in the TG+ model and the need for refined approaches in FA treatment development.

Friedreich’s ataxia treatment’s sexual dimorphism