Iron regulatory protein deficiency compromises mitochondrial function in murine embryonic fibroblasts

Huihui Li, Hongting Zhao, Shuangying Hao, Longcheng Shang, Jing Wu, Chuanhui Song, Esther G. Meyron-Holtz, Tong Qiao & Kuanyu Li; Scientific Reportsvolume 8, Article number: 5118 (2018) doi:10.1038/s41598-018-23175-y

Overexpression of human ISCU and frataxin in Irp1 or Irp2-null cells was able to rescue the defects in iron-sulfur cluster biogenesis and mitochondrial quality.

 Iron regulatory protein deficiency compromises mitochondrial function in murine embryonic fibroblasts