Regulation of fatty acid metabolism by mTOR in adult murine hearts occurs independently of changes in PGC-1α. Yi Zhu, Jamie Soto, Brandon Anderson, Christian Riehle, Yi Cheng Zhang, Adam R Wende, Deborah Jones, Donald A. McClain, and E. Dale Abel, Am J Physiol Heart Circ Physiol ajpheart.00877.2012; published ahead of print April 26, 2013, doi: 10.1152/ajpheart.00877.2012
In conclusion, mTOR regulates mitochondrial fatty acid utilization but not glucose utilization in the heart via mechanisms that are independent of changes in PGC expression.
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