A Clinical Study to Evaluate the Effect of MIN-102 on the Progression of Friedreich's Ataxia in Male and Female Patients (FRAMES)

ClinicalTrials.gov Identifier: NCT03917225.

Double-Blind, Placebo-controlled Study on the Effects of MIN-102 on Biochemical, Imaging, Neurophisyiological, and Clinical Markers in Patients With Friedreich's Ataxia.
Sponsor: Minoryx Therapeutics, S.L.

Locations
Belgium
Hôpital Erasme-ULB Not yet recruiting
Brussels, Belgium, B-1070
Contact: Prof. Massimo Pandolfo
France
ICM, Groupe Hospitalier Pitié Salpêtrière Not yet recruiting
Paris, France, 75646
Contact: Prof. Alexandra Durr
Germany
Universitätsklinikum RWTH Not yet recruiting
Aachen, Germany, 52074
Contact: Prof. Jörg B Schulz
Spain
Hospital Sant Joan de Déu Not yet recruiting
Barcelona, Spain
Contact: Dr. Alejandra Darling
Hospital Universitario La Paz Recruiting
Madrid, Spain, 28046
Contact: Dr. Francisco Javier Rodríguez de Rivera

Association between restless legs syndrome and other movement disorders

Hortensia Alonso-Navarro, Elena García-Martín, José A.G. Agúndez, View ORCID ProfileFélix Javier Jiménez-Jiménez; Neurology. 2019 Apr 19. pii: 10.1212/WNL.0000000000007500. doi: 10.1212/WNL.0000000000007500.

Review of PubMed from 1966 to September 2018 and identification of references of interest for the topic. A meta-analysis of eligible studies on the frequency of RLS in patients with PD and controls using Meta-DiSc1.1.1 software and using the PRISMA guidelines was performed.

Several studies have also suggested that RLS could be an early clinical feature of PD. RLS symptoms are frequent in multiple system atrophy, essential tremor, Tourette syndrome, Friedreich ataxia, and spinocerebellar ataxia type 3 as well.