Saturday, February 22, 2014

Generation and Characterisation of Friedreich Ataxia YG8R Mouse Fibroblast and Neural Stem Cell Models

Generation and Characterisation of Friedreich Ataxia YG8R Mouse Fibroblast and Neural Stem Cell Models . Chiranjeevi Sandi, Madhavi Sandi, Harvinder Jassal, Vahid Ezzatizadeh, Sara Anjomani-Virmouni, Sahar Al-Mahdawi, Mark A. Pook; PLoS ONE 9(2): e89488. doi:10.1371/journal.pone.0089488

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Genomic Instability in Pluripotent Stem Cells: Implications for Clinical Applications

Genomic Instability in Pluripotent Stem Cells: Implications for Clinical Applications. Suzanne E. Peterson and Jeanne F. Loring; The Journal of Biological Chemistry, 289, 4578-4584. 10.1074/jbc.R113.516419 February 21, 2014

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There are several examples of dramatic genomic changes that appear when cells are reprogrammed. Studies of some trinucleotide repeat diseases have reported changes in the repeat length following reprogramming. Specifically, in Friedreich ataxia, the GAA/TTC triplet repeat length in the FXN (frataxin) gene appeared to change following reprogramming of patient fibroblasts

Although the probability of an FDA-approved hPSC-derived cell therapy causing harm to a patient appears to be low, the consequences of adverse events are enormous. There is an important lesson from the failures in early gene therapy trials. If even one patient is harmed in an FDA-approved trial using hPSC derivatives, all further trials will be in serious jeopardy, and the promise of stem cell therapy will be put on indefinite hold.

The Neuroprotective Role of Acupuncture and Activation of the BDNF Signaling Pathway

The Neuroprotective Role of Acupuncture and Activation of the BDNF Signaling Pathway. Lin, Dong; De La Pena, Ike; Lin, Lili; Zhou, Shu-Feng; Borlongan, Cesar V.; Cao, Chuanhai; International Journal of Molecular Sciences. 2014; 15(2):3234-3252.

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Global Identification of Genes Affecting Iron-Sulfur Cluster Biogenesis and Iron Homeostasis

Global Identification of Genes Affecting Iron-Sulfur Cluster Biogenesis and Iron Homeostasis . Ryota Hidese, Hisaaki Mihara, Tatsuo Kurihara and Nobuyoshi Esaki; J. Bacteriol. March 2014 vol. 196 no. 6 1238-1249; Published ahead of print 10 January 2014, doi: 10.1128/JB.01160-13

Drosophila models for studying iron-related neurodegenerative diseases.

Drosophila models for studying iron-related neurodegenerative diseases. Zhu ZJ, Wu KC, Qian ZM, Yung WH, Ke Y.; Acta Physiologica Sinica, February 25, 2014, 66(1): 47–54; DOI: 10.13294/j.aps.2014.0007 http://www.actaps.com.cn

4.1 FRDA Drosophila models


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