NRF2 activators: how do they work and how advanced is their clinical use?

Antonio Cuadrado, Free Radical Biology and Medicine, Volume 96, Supplement 1, July 2016, Pages S6-S7, ISSN 0891-5849, doi:10.1016/j.freeradbiomed.2016.04.043

The transcription factor, nuclear factor (erythroid-derived 2)-like 2 (NRF2) is a master regulator of cell homeostasis that regulates the expression of antioxidant and cytoprotective genes. The synthetic triterpenoid CDDO-methyl ester (also known as bardoxolone methyl) is being studied for therapy of diabetic nephropathy, pulmonary arterial hypertension, melanoma and Friedreich ataxia.