Individualized exercise and NAD+ precursor supplementation in Friedreich’s Ataxia: a randomized controlled trial

Lin, Kimberly Y. and Lin, Kimberly Y. and Bucha, Anna and Bucha, Anna and McSweeney, Kara and McSweeney, Kara and Wade, Kristin L. and Wade, Kristin L. and Karaj, Antoneta and Tamaroff, Jaclyn and Tamaroff, Jaclyn and O'Malley, Shannon and O'Malley, Shannon and Chung, Nicole M. and Chung, Nicole M. and Cilenti, Nicolette A. and Cilenti, Nicolette A. and Wanner, Julianne and Wanner, Julianne and Adzika, Gabriel K. and Adzika, Gabriel K. and Mesaros, Clementina and Blair, Ian A. and Blair, Ian A. and Rojsajjakul, Teerapat and Rojsajjakul, Teerapat and Serai, Suraj and Serai, Suraj and Farmer, Jennifer and Farmer, Jennifer and Bryant, Kyle and Bryant, Kyle and Lu, Yingying and Lu, Yingying and Harhay, Michael and Harhay, Michael and Weber, David R. and Weber, David R. and Paridon, Stephen M. and Paridon, Stephen M. and Seifert, Erin and Putt, Mary E. and Zamani, Payman and Zamani, Payman and Baur, Joseph A. and Lynch, David R. and Lynch, David R. and McCormack, Shana E. and McCormack, Shana E., Individualized exercise and NAD+ precursor supplementation in Friedreich’s Ataxia: a randomized controlled trial. doi:10.2139/ssrn.5698224. 

Interpretation: NR plus exercise for 12 weeks was safe and increased cardiovascular fitness in children and adults with FRDA. Adding NR to exercise could be considered as part of a comprehensive treatment approach.